摘要
COPD、哮喘、支气管扩张及肺囊性纤维化等气道高分泌疾病中的分泌物潴留除了与黏蛋白的绝对量增多有关，还与黏蛋白／水盐比例失衡密切相关。气道上皮细胞的各种通道蛋白如Na^＋、Cl^-和水通道等参与气道表面液体中水盐跨膜转运，通过调节黏蛋白／水盐比例来影响黏液的总量和黏滞度，在抗黏液高分泌中显示出广泛的前景。
COPD,asthma,bronchiectasis and lung cystic fibrosis are airway hypersecretary diseases. Secretion stasis is closely related to airway surface liquid （ASL） composition （mucin-to-water and salt ratio）, except for its relationship with the quantity of mucin. Various channel proteins resided on airway epithelium,such as Na^＋, Cl^- and water channels involved in water and ion transepithelium transport, regulating volume and viscoelasticity of mucus. Deeper understanding of these channel proteins＇ function should lead to rational design of antisecretory drugs for treatment of airway mucus hypersecretion.
出处
《国际呼吸杂志》
2007年第11期871-873,共3页
International Journal of Respiration
关键词
气道表面液体
上皮钠通道
CL^-通道
水通道
Airway surface liquid
Epithelial sodium channel
Chloride channel
Aquaporin
