摘要
类风湿性关节炎是一种全身系统性免疫疾病,其发病原因不明,发病过程中有多种免疫细胞和细胞因子参与。NO是一种多功能的细胞因子,可以通过调节核因子、多种细胞因子和金属蛋白酶的水平等多种途径参与类风湿性关节炎的病理进程。目前选择性iNOS抑制剂已经成为抗类风湿性关节炎药物的重要研究方向。
Rheumatoid arthritis （RA） is a systemic, inflammatory autoimmune disease of unknown etiology. Many cytokines participate in RA proceeding during which NO is a active molecule influencing RA＇s proceeding at various stages. The relationship of NO and RA are discussed in this paper, as well as the recent research of selective iNOS inhibitors.
出处
《药学与临床研究》
2007年第3期175-178,共4页
Pharmaceutical and Clinical Research
