期刊文献+

蛋白质组学在围产医学领域中的应用

Application of proteomics in perinatology
下载PDF
导出
摘要 蛋白质组学是整体、动态、定量地研究蛋白质组成、功能和相互关系的一门新兴学科,蛋白质组学的技术路线包括样品的制备、分离、蛋白质的鉴定和生物信息的分析。目前蛋白质组学技术在围产医学领域的研究主要侧重于疾病的发生机制、早期诊断及寻找疾病的生物标志物。该文就其在该领域中的研究进展作以综述。 Proteomics is a newly emerging science, which studies structure, function and interactions of proteins generally, dynamically and quantitatively. The technology includes sample preparation and separation, identification of protein and analysis of bioinformation. At present, the research on proteomics in field of perinatology emphasizes on mechanism, early diagnosis and searching for biomarkers of the perinatal diseases. In this article, we summarized progress in research on proteomics in perinatology.
作者 林晶 何晓宇
出处 《中国妇幼健康研究》 2007年第3期227-229,共3页 Chinese Journal of Woman and Child Health Research
关键词 蛋白质组学 妊娠期高血压疾病 胎膜旱破 绒毛膜羊膜炎 proteomics hypertensive disorder complicating pregnancy premature rupture of membranes (PROM) chorioamnionitis
  • 相关文献

参考文献15

  • 1Tinnakom C.A proteomic approach for the identification of biological markers of preeclampsia[J].Am J Obster and Gynecol,2003,11(1):S95. 被引量:1
  • 2Mert O B,Ray B S,Joshua A,et al.Serum proteomics distinguish preeclamptic women from normal women[J].Obstct & Gynecol,2003,4:S82. 被引量:1
  • 3Watanabe H,Hamada H,Yanada N,et al.Proteome analysis reveals elevated serum levels of clustein in patients with preeclampsia[J].Proteomics,2004,4(2):537-543. 被引量:1
  • 4Koy C,Heitner J C,Woisch R,et al.Cryodetector mass spectrometry profiling of plasma sample for HELLP diagnosis:An exploratory study[J].Proteomics,2005,5(12):3079-3087. 被引量:1
  • 5Norwitz E R,Tsen L C,Park J S,et al.Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia[J].Am J Obstet Gynecol,2005,193 (3):957-964. 被引量:1
  • 6Buhimschi I A,Guomao Z,Funai,et al.Proteomics analysis of urine in preeclampsia:A novel diagnosis for an old disease[J].Am J Obstet Gynecol,2006,193(6):S15. 被引量:1
  • 7Hardy D B,Yang K.The expression of 11 beta-hydroxysteroid de hydrogenase type 2 is induced during trophoblast differentiation:Effect of hypoxia[J].J Clin Endocrinol Metab,2002,87(8):A3696-A3701. 被引量:1
  • 8Gratton R J,Gandley R E,Genbacev O,et al.Conditioned medium from hypoxic cytotrophoblasts alters arterial function[J].Am J Obstet Gynecol,2001,184 (5):984-990. 被引量:1
  • 9Hoang V M,Foulk R,Clauser K,et al.Functional proteomics:examining the effects of hypoxia on the cytotrophoblast protein repertoire[J].Endocrinology,2003,144 (4):1147 -1154. 被引量:1
  • 10Vuadens F,Benay C,Crettaz D,et al.Identification of biologic markets of the premature rupture of fetal membranes:proteomic approach[J].Proteomics,2003,3 (8):1521-1525. 被引量:1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部