摘要
目的探讨解脲支原体感染与胎膜早破的相关性。方法应用荧光定量PCR技术对30例胎膜早破孕妇和30例非胎膜早破孕妇((对照组)宫颈分泌物进行解脲支原体定量检测。结果胎膜早破组解脲支原体感染率:胎膜早破组63.33%(19/30);对照组解脲支原体感染率为20%(6/30)。两组比较有显著性差异(P<0.05);解脲支原体定量≥1.00×105cp/μL时,胎膜早破的发生率为86.36%,与<1.00×105cp/μL时对照组比较有极显著性差异(P(0.01);并且胎膜早破的发生与解脲支原体定量密切相关,相关系数为1.00(P<0.05)。结论孕妇宫颈解脲支原体感染是胎膜早破的重要原因,解脲支原体定量≥1.00×105cp/μL时通过影响胎膜胶原代谢,可作为区分感染与无症状携带的标准。
Objective To study correlation between ureaplasma urealyticum （UU） infection and premature rupture of membranes （PROM）. Methods Thirty pregnant women with PROM and thirty normal pregnant women without PROM were detected for UU infection in their cervical excretion in fluorescence quantitative PCR technique. Results The UU positive rate of pregnant women with premature rupture of membranes was 63.33% （19/30）. While the UU infection rate of normal pregnant women without PROM was 20% （6/30）. There was a very significant difference in the UU infection rate between the two groups （ P 〈 0.01 ）. The incidence rate of PROM was 86.36% when the quantity of UU DNA≥1. 00 ×10^5cp/μL, and there was a signifieant difference as compared with 〈 1.00 ×10^5cp/μL of quantity of UU DNA in the control group（P 〈0.01 ）. PROM was correlated with the quantity of UU DNA linearly and the correlation coefficient was 1.00 （ P 〈 0.05 ）. The incidence of PROM of pregnant women was correlated with UU quantity in their cervical excretion. Conclusion UU-DNA quantity in the cervical excretion is an important cause of PROM. When the quantity of UU DNA ≥ 1.00 ×10^5cp/μL, UU can cause PROM by influencing metabolism of collagen in the fetal membranes and increasing degeneration of the collagen.
出处
《中国妇幼健康研究》
2007年第3期194-196,F0003,共4页
Chinese Journal of Woman and Child Health Research
关键词
解脲支原体
荧光定量PCR
胎膜早破
相关性
ureaplasma urealyticum（ UU ）
fluorescence quantitative PCR
premature rupture of membranes （PROM）
correlation
