摘要
背景:传统中医药对慢性乙型肝炎有较好的治疗效果,但其作用机制尚不完全清楚。目的:观察苦参素联合复方丹参对慢性乙型肝炎患者肝纤维化血清学指标、肿瘤坏死因子(TNF)-α和瘦素水平的影响。方法:慢性乙型肝炎后肝纤维化患者60例,随机分为两组。试验组30例,予苦参素联合复方丹参片治疗,对照组30例,予水飞蓟素片治疗,疗程均为6个月。测定两组患者治疗前后肝纤维化血清学指标:透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)和层黏蛋白(LN)以及TNF-α、瘦素水平。结果:与治疗前比较,治疗后试验组血清HA、Ⅳ-C和LN水平均明显下降,其中尤以HA、Ⅳ-C下降显著(P<0.01),且TNF-α和瘦素水平亦有显著下降(P<0.01);对照组治疗前后肝纤维化指标、TNF-α和瘦素水平无明显变化(P>0.05)。治疗后试验组各项肝纤维化血清学指标和TNF-α、瘦素水平均显著低于对照组(P<0.05)。结论:苦参素联合复方丹参具有明显的抗乙型肝炎后肝纤维化的作用,且用药安全,其作用机制可能与下调TNF-α和瘦素表达有关。
Background： The use of Chinese traditional medicine had demonstrated beneficial effect on the course of chronic hepatitis B, but its mechanism is not fully known. Aims： To observe the effect of oxymatrine combined with compound Salvia miltiorrhiza on serological markers of liver fibrosis, tumor necrosis factor （TNF）-ct and leptin levels in patients with chronic hepatitis B. Methods： Sixty patients with chronic hepatitis B and liver fibrosis were randomly divided into two groups, each 30 in number. Patients in the treated group （n=30） received oxymatrine combined with compound Salvia miltiorrhiza, and the control group （n=30） received silymafin, both for 6 months. Serological markers of liver fibrosis as hyaluronic acid （HA）, type Ⅳ collagen （Ⅳ-C）, laminin （LN） and levels of TNF-α and leptin were determined before and after treatment. Results： In the treated group, levels of HA, Ⅳ-C and LN decreased significantly after treatment, in particular, the HA and Ⅳ-C （P〈0.01）; The TNF-α and leptin levels also decreased significantly after treatment （P〈0.01）. Whereas in the control group, changes of serological markers of liver fibrosis were not significant （P〉0.05）, that of TNF-α and leptin levels was also insignificant. Comparing the two groups, the serological markers of liver fibrosis, TNF-α and leptin levels in the treated group were significantly lower than those in the control group （P〈0.05）. Conclusions： Oxymatrine combined with compound Salvia mihiorrhiza have obvious ameliorating effect on liver fibrosis in patients with chronic hepatitis B and the mechanism involved might be related to the down-regulation of TNF-α and leptin levels.
出处
《胃肠病学》
2007年第5期288-290,共3页
Chinese Journal of Gastroenterology
基金
上海市南汇区卫生系统学科带头人培养计划资金资助(No.南卫医政2003-8)
关键词
肝炎
乙型
慢性
肝硬化
苦参素
复方丹参片
肿瘤坏死因子-Α
瘦素
Hepatitis B, Chronic
Liver Cirrhosis
Oxymatrine
FUFANG DANSHEN TABLET
Tumor Necrosis Factor-alpha
Leptin
