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甘草酸二铵镇咳作用的研究 被引量:7

Study on Antitussive Function of Diammonii Glycyrrizinatis
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摘要 目的:建立咳嗽的记录方法并观察甘草酸二铵的镇咳作用。方法:以氨水引咳建立动物咳嗽模型筛选合格小鼠,选取40只随机分成4组,分别腹腔注射NS、0.0625%、0.125%、0.25%甘草酸二铵溶液,20min后,氨水引咳,记录3min内咳嗽次数。结果:甘草酸二铵各组小鼠咳嗽次数较生理盐水组明显减少(P≤0.01),甘草酸二铵各组组间比较均具有明显差异(P≤0.01)。结论:甘草酸二铵具有明显的镇咳作用。 Objective: To found the record device forcough and to observe the antitussive function of Diammonii glycyrrizinatis. Methods: 40 qualified mice were choosed and divided into four set at radom , then were i. p NS. 0. 0625%.0. 125%.0. 25% Diammonium Glycyrrhizinatis solution respectively. Afer 20 min, the cough of the mice was induced by ammonia aerosol and the number of cough during three minute was recorded by a medlab system. Results: The number of cough in mice of every Diammonium Glycyrrhizinat group is lower than that of the model control group (P≤0. 01), the number of cough in mice of every set has the obvious difference comparatively (P≤0. 01). Conclusion: The Diammonium Glycyrrhizinatis has the obvious antitussive function.
出处 《数理医药学杂志》 2007年第3期372-373,共2页 Journal of Mathematical Medicine
关键词 甘草酸二铵 氨水 小鼠 镇咳作用 diammonium glycyrrhizinate ammonia mice antitussive function
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