摘要
目的了解大肠埃希菌对抗生素耐药性变迁,为临床治疗提供参考。方法菌株鉴定和药敏试验采用ATB全自动微生物分析仪进行测定,超广谱β-内酰胺酶（ESBLs）采用双纸片协同法。结果从2001-2005年检出的大肠埃希菌对青霉素类药物耐药率最高,对亚胺培南耐药率最低,氨基糖苷类和第三代头孢菌素药物具有较好的体外抗菌活性,大肠埃希菌超广谱β-内酰氨酶（ESBLs）的发生率呈逐年上升的趋势,分别是8.5%、16.4%、19.3%、25.4%、27.8%。结论随着抗生素的广泛使用,大肠埃希菌的耐药性逐渐上升,要加强对其的耐药性监测,指导临床合理用药。
Objective To understand the variation of resistance of Escherichia coli to antibiotics. Methods The strains of Escherichia coli were differentiated and their sensitivity to antibiotics were determined by using ATB automatci microorganism analysing system. The double - disk synergy tests were carried out with extended spectrum β - lactamases （ESBLS）. Results From 2001 to 2005 the resistant rate of Escherichia coil to penicillin was the highest, the resistant rate to imipenem was the lowest; high bacterium - inhibition activity of Escherichia coli to cephalosporin of the third generation and amlnoglycosldes was observed in vitro, the prevalence of ESBLS - producing isolates of Escherichia coli were increasing year after year, being 8.5%, 16.4%, 19. 3 %, 25.4 %, 27.8 % from 2003 to 2006. Conclusion The drug rsistance of Escherichia coli has been grndually on the rise along with the wide use of antibiotics. Thus monitoring of drug resistance of Escherichia coli be strengthened for guiding reasonable use of antibiotic in clinial practice.
出处
《中国热带医学》
CAS
2007年第6期1010-1011,共2页
China Tropical Medicine
