摘要
目的探讨血管内皮生长因子(VEGF)和可溶性血管细胞黏附分子-(sVCAM-1)在过敏性紫癜(HSP)儿童表达的意义。方法HSP患儿58例。其中急性期30例,缓解期28例。正常对照组23例。采用固相酶联免疫吸附法(ELISA)分别检测其血浆VEGF、sVCAM-1水平,并进行两两比较和相关分析。结果HSP急性期患儿血浆VEGF、sVCAM-1水平明显高于缓解期和对照组(Pa<0.01),且二者呈正相关(r=0.939P<0.001)。结论VEGF、sVCAM-1可能参与HSP发病过程,对病情发展及预后判断有一定意义。
Objective To study the expression and clinical significance of vascular endothelial growth factor（VEGF） and soluble vascular cell adhesion molecule - 1 （ sVCAM - 1 ） in children with Henoch - Schonlein purpura（HSP）. Methods The levels of plasma VEGF and sVCAM - 1 were measured in 58 children with HSP and 23 normal children by enzyme - linked immunosorbent assay （ ELISA ）, respectively. Results The plasma levels of VEGF and sVCAM - 1 of HSP children at acute stage were significantely higher than those of HSP children at the remission stage and those of the controls （ Pa 〈 0.01 ）. The plasma levels of VEGF of HSP children at the acute stage were positively correlated with the levels of sVCAM - 1 （r = 0. 939 P 〈 0. 001 ）. Conclusion VEGF and sVCAM - 1 may play a crucial role in pathogenesis of HSP.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第9期682-682,684,共2页
Journal of Applied Clinical Pediatrics
关键词
血管内皮生长因子
可溶性血管细胞黏附分子-1
紫癜
过敏性
儿童
vascular endothelial growth factor
soluble vascular cell adhesion molecule - 1
Henoch - Schonlein purpura
child
