摘要
垂体瘤是颅内常见的良性肿瘤,但却存在着较高的复发率。Jefferson于1940年提出侵袭性垂体腺瘤的概念,认为这部分垂体腺瘤的生物学行为介于良性垂体瘤和垂体癌之间。随后人们从分子生物学、病理学等多个角度对侵袭性腺瘤的发病机制进行了探讨,以期寻找到特异性的侵袭性指标。众所周知,细胞增殖能力的增强和凋亡的抑制是导致肿瘤恶性生物学行为的重要机制。但对垂体瘤的研究却发现有为数不少的侵袭性垂体腺瘤并不呈现高细胞增殖状态,而凋亡的研究则更是出现了不同甚至相反的结果,那到底是什么原因导致了侵袭性的形成呢?本文从细胞增殖和凋亡各自的临床意义以及其联合检测的角度探讨侵袭性的确切机制。
pituitary adenomas is a common intraeranial benign tumors, but there is a rather high incidence of relapse. So in 1940 Jefferson raise the concept of invasive pituitary adenomas, he think the behavior of invasive pituitary adenomas is between benign aderaomas and malignant pituitary cancer. After that medical workers investigate the mechanism of invasiveness from moculeobio- logical and pathological aspects, in order to find specific markers of invasiveness. As we all know that high cell proliferation and （or） inhibitated cell apoptosis is the main reason leading to malignant behaviour of tumors. But some reseachers found that some invasive pituitary adenomas have a rather low cell proliferation, and apoptosis of invasive adenomas differs very greatly, for what reason？ In this article we compare the relationship between cell proliferation and apoptosis seperately with invasiveness, and the relationship of combing detection of cell proliferation and apoptosis with invasiveness, then to ling the exact mechanism of invasive behaviour of pituitary adenomas.
出处
《医学与哲学（B）》
2007年第5期55-56,59,共3页
Medicine & Philosophy(B)
关键词
垂体瘤
侵袭性
增殖
凋亡
诊断
pituitary adenomas, invasive, proliferation, apoptosis, diagnosis
