摘要
目的:探讨冠心病患者不同心功能级别Tei指数和脑钠肽(BNP)的变化及其相关性。方法:按照NYHA心功能分级将入选者分为4组:选取冠脉造影正常排除冠心病心功能Ⅰ级者(20例)为对照组(A组);心功能Ⅱ级者为B组,心功能Ⅲ级者为C组,心功能Ⅳ级者为D组,每组20例,B、C、D组均为经冠脉造影证实至少一支主要冠状动脉狭窄大于70%的冠心病患者;超声心动图测定左室射血分数(LVEF)、二尖瓣口舒张早期与舒张晚期血流峰值速度比值(E/A)、Tei指数;同期取血检测BNP浓度。结果:随着心功能级别的升高Tei指数与BNP逐渐增加(P<0.05),4组的Tei指数分别为0.40±0.04、0.50±0.05、0.62±0.08、0.78±0.07;4组的BNP分别为(44.62±15.21)ng/L、(197.45±41.84)ng/L、(410.70±278.18)ng/L、(774.75±371.96)ng/L;4组LVEF分别为67.52±4.54、64.85±5.40、51.85±9.73、43.50±8.46,A、B2组差别无统计学意义,余各组间差别有统计学意义(P<0.05);4组E/A分别为1.06±0.27、0.83±0.20、0.80±0.19、0.78±0.31,A组与B、C、D组差别均有统计学意义(P<0.05),后3组之间差别无统计学意义。Tei指数与BNP呈正相关(r=0.90),LVEF与BNP呈负相关(r=-0.68),E/A与BNP无线性关系。结论:Tei指数与BNP存在较好的相关性,是一种无创、简便、敏感、准确、综合评价心脏整体功能的新指标。
Objective：To investigate the correlation between the Tel index and BNP and their changes in the coronary artery disease patients with different cardiac function. Methods： Twenty patients with normal heart function were in group A. Sixty patients with coronary artery disease who were diagnosed by coronary artery angiography were divided into 3 groups by the degree of heart failure. Twenty patients with NYHA grade Ⅱ were in group B, 20 patients with NYHA grade Ⅲ in group C, and 20 patients with NYHA grade Ⅳ in group D. The diagnostic criteria of coronary artery disease was that there was a stenosis more than 70% in left main artery or one main branch artery at least. Left ventricular ejection fraction （LVEF）, E/A, and Tei index were measured by echocardiography. Plasma BNP was assayed at the same time. Results： Tei index and BNP increased with the heart dysfunction aggravated （P 〈 0.05）. Tei index of the 4 groups were 0.40±0.04, 0.50＋0.05, 0.62±0.08, and 0.78±0.07 respectively. BNP of the 4 groups were （44.62±15.21） ng/L, （197.45±41.84） ng/L,（410.7±278.18） ng/L, and （774.75±371.96） ng/L respectively. There were significant differences in any two groups （P 〈 0.05）. LVEF of the 4 groups were 67.52±4.54, 64.85±5.4, 51.85±9.73, and 43.50±8.46 respectively. There was no significant difference in group A and B, and there were significant differences in the other groups （P 〈 0.05）. E/A of the 4 groups were 1.06±0.27, 0.83± 0.20, 0.80±.19, and 0.78±0.31 respectively. There were significant differences in group A and group B, C and D （P 〈 0.05）, while, there was no significant differences in group B, C and D （P 〉 0.05）. There was a significant negative correlation between LVEF and BNP （OR= -0.68, P〈 0.05）. There was also a significant positive correlation between Tel index and BNP （OR = 0.90, P 〈 0.05）. There was no significant correlation between E/A and BNP （OR= 0.30, P〉 0.05）. Conclusion： There is a good correlation between
出处
《天津医药》
CAS
北大核心
2007年第5期329-331,共3页
Tianjin Medical Journal
