摘要
胰腺癌是消化系统常见的恶性肿瘤,目前多学科、多中心联合的综合治疗已经在许多方面取得了一定的进展,其综合治疗包括外科治疗、化疗、放疗、物理及生物治疗等。胰腺癌的治疗以手术为主,实行合理的手术切除可以改善病人的长期生存率及生活质量。放射治疗可分为与手术联合的辅助性放疗及姑息性放疗,术前放化疗,可以提高手术切除率,并减少肿瘤扩散,术中放疗可以缓解疼痛,提高生存率,术后辅助放化疗的作用仍有争议。化疗分为全身和区域性化疗,区域性化疗为选择性动脉给药,理论上有诸多优势,但仍需数据支持。物理治疗和生物治疗在胰腺癌的治疗中也已经得到广泛的重视。但只有建立以手术切除为主,联合放疗、化疗、物理及生物治疗的综合治疗体系,才有可能提高病人的长期生存率,改善病人的生活质量。
Pancreatic carcinoma is a common malignancy of gastrointestinal system. Multi-department and multi-center combined therapy has great developments in many areas, including surgery, chemotherapy, radiotherapy, physical, biological-therapy and so on. Surgical management is a major therapy, including redical operation and palliative operation. Rational operation could improve the patients＇long-term survival rate and the quality of life. Radiotherapy includes accessory irradiation combined with operation and palliative irradiation. Preoperational radiotherapy and chemotherapy could improve resectional rate of operation and decrease the tumor dissemination. Intraoperation irradiation includes intraoperative electron radiation therapy, intraoperative radiational partical implantment and so on. It could relieve pain and enhance survival rate, but the effect of post-operation adjuvant radiotherapy is still controversial. Chemotherapy consists of intravenous chemotherapy and regional chemotherapy, combined chemotherapy couldn＇t significantly prolong the survival term of patients with pancreatic carcinoma compared with single chemotherapy. Regional chemotherapy is selective artery administration and has many advantages in theory. Physical and biological-therapy also get widely recommendations. But only combined therapy consisting of surgical resection, radiotherapy, chemotherapy, physical and biological-therapy could increase the long-term survival rates and improve the life quality of the patients with pancreatic carcinoma.
出处
《中国介入影像与治疗学》
CSCD
2007年第2期154-158,共5页
Chinese Journal of Interventional Imaging and Therapy
关键词
胰腺癌
综合治疗
Pancreatic carcinoma
Multimodality treatment
