摘要
目的探讨加替沙星治疗社区获得性肺炎的疗效及不良反应的发生。方法入选2005年2月1日至2006年1月31日我医院的CAP住院患者107例,随机分成A、B两组。A组(54例)给予生理盐水250ml+加替沙星400mg静脉滴注,qd,治疗14d;B组(53例)给予生理盐水100ml+头孢呋辛2.0g静脉滴注,q12h,治疗14d。依据症状、体征、实验室检查恢复以及致病菌清除评价疗效;依据治疗前后肝、肾功能、血糖改变及恶心、呕吐消化道反应发生率评价不良反应。结果两组治愈率分别为57.4%和54.7%,通过Ridit检验,统计学无显著性差异;有效率分别为94.4%和88.7%,有显著性差异(P<0.05);两组细菌清除率分别为88.9%和94.1%,无显著性差异(P>0.05)。两组治疗前后肝、肾功能、血糖改变及恶心、呕吐消化道反应发生率均无统计学差异。结论应用加替沙星治疗CAP,能达到非常满意的临床效果与满意的细菌清除率,且不良反应发生率低,值得临床推广。
Objective To investigate the efficacy and adverse effects of gatifloxacin on community acquied pneumonia （CAP）. Methods One hundred and seven cases of CAP hospitalized patients were selected from the Fifth Affiliated Hospital of Zhengzhou University, from 1st Feb, 2005 to 31st Jan, 2006. They were randomly divided into group A and B. Group A （54cases）, were treated with normal saline （250ml） and gatifioxacin （400mg） intravenous drip per day for 14 days; Group B （53cases）, were treated with normal saline （100ml） and cefuroxime （2.0g） intravenous drip per 12 hours for 14 days. The efficacies were evaluated according to the therapeutic indices, including symptom, sign, recovery of laboratory examination and clear- ance rate of pathogenic bacteria and the adverse reaction indices, including the shift of liver, renal functions and blood sugar pre/post-treatment, the occurrence of alimentary tract reactions such as nausea, vomiting. Results For gatifloxacin and cefuroxime, the cure rate of CAP were 57.4% and 54.7% respectively, there was no significant difference with Ridit test. The efficacy rates were 94.4% and 88.7% respectively with significant differences （P〈0. 05）. The clearance rate of pathogenic bacteria were 88.9% and 94.1% respectively （P〉0.05）. No statistic difference was shown between the two groups for adverse reactions. Conclusion Satisfactory clinical efficacies and clearance of pathogens can be achieved with gatifloxacin therapy of CAP with low ADR occurrence. Gatifloxacin could be used for clinical CAP treatment.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2007年第5期313-315,共3页
Chinese Journal of Antibiotics
关键词
加替沙星
社区获得性肺炎
临床疗效
细菌清除率
Gatifloxacin
Community acquired pneumonia
Clinical therapeutic effects
Clearance of pathogens
