摘要
目的:评价高龄危重患者BPH经皮冷冻的临床疗效。方法:使用ENDCARE冷冻手术系统,对72～91岁,同时伴有明显心肺功能障碍的21例BPH患者实施B超引导下的氩氦刀冷冻治疗,观察术后前列腺活检、前列腺超声图像、尿流率、血清PSA等变化。结果:术后前列腺组织出现变性、坏死,表现为完全消融现象;氩氦刀治疗前后平均尿流率分别为(3.8±2.1)、(17.0±5.8)ml/s(P<0.01);术前血清PSA(3.7±2.4)μg/L,术后1周(22.6±13.1)μg/L,与术前相比明显增高(P<0.01),术后4周(1.7±1.4)μg/L,与术前相比明显降低(P<0.05)。结论:经皮氩氦刀冷冻治疗BPH近期疗效满意,是高龄危重患者较好的治疗方法。
Objective ： To study the clinical effect of cryosurgical ablation for aged patients with severe benign prostate hyperplasia. Methods ： Twenty-one 72-91 years old patients with severe benign prostate hyperplasia accompanied with cardiopulmonary dysfunction were treated by the ENDOCARE cryo-care surgery system with cryo-probes guided by type B ultrasound. Observations were made of the post-operation prostate biopsy and ultrasonogram as well as the changes of the urinary flow rate （UFR） and prostate-specific antigen （PSA）. Results ： Degeneration and necrosis of the prostate tissues were found after the operation, with the signs of being completely melted. The mean UFRs before and after the operation were （ 3.8 ± 2.1 ） ml/s and （ 17.0 ±5.8 ） ml/s, respectively （ P 〈 0.01 ）. Compared with the pre-operation level of PSA （ [ 3.7 ±2.1 ] μg/L）, the 1-week post-operation level was significantly higher （ [22.6± 13.1] μg/L） （P〈0.01）, while the 4-week post-operation level significantly lower （ [1.7 ±1.4] μg/L） （P〈0.05）. Conclusion ： Cryosurgical ablation, with satisfactory short-term curative effect, is a desirable option for the treatment of aged patients with severe benign prostate hyperplasia.
出处
《中华男科学杂志》
CAS
CSCD
2007年第5期421-423,共3页
National Journal of Andrology
关键词
良性前列腺增生
冷冻治疗
前列腺特异性抗原
benign prostate hyperplasia
cryosurgical ablation
prostate-specific antigen
