摘要
目的探讨子宫内膜异位症（EM）患者腹腔液白细胞介素8（IL-8）、肿瘤坏死因子仅（TNF-α）的水平变化及临床意义。方法应用酶联免疫吸附法（ELISA）测定40例EM患者（Ⅰ-Ⅱ期19例、Ⅲ-Ⅳ期21例）及38例非内异症患者（对照组）患者腹腔液中IL-8及TNF-α的水平。结果EM组患者腹腔液IL-8、TNF-α的水平[（75．81±65．92）、（51．46±24．77）pg／ml]均高于对照组[（30．58±19．94）、（26．82±17．34）pg／ml]，差异有统计学意义（P〈0．05）；EM组Ⅲ-Ⅳ期患者腹腔液中IL-8、TNF-α水平[（117．41±87．92）、（70．35±29．14）pg／ml]高于Ⅰ-Ⅱ期患者[（48．02±19．11）、（32．68±13．26）pg／ml]，差异有统计学意义（P〈0．05）；与对照组增生期和分泌期腹腔液中IL-8、TNF-α差异无统计学意义（P〉0．05）；EM组腹腔液中IL-8、TNF-α的水平无明显相关性。结论EM患者腹腔液中IL-8、TNF-α水平增高，且Ⅲ-Ⅳ期浓度高于Ⅰ-Ⅱ期，提示腹腔巨噬细胞产生的细胞因子在子宫内膜异位症的发生发展中有一定意义。
Objective To investigate the levels of IL-8, TNF-α in the peritoneal fluid of patients with endometriosis （EM）and their clinical significance. Methods The levels of IL-8 ,TNF-α in the peritoneal fluid of 40 patients with EM and 38 women without EM （ as controls） were measured with ELISA. Results Higher levels of IL-8 and TNF-α were observed in women with EM （75.81 ± 65.92, 51.46 ± 24.77 ） pg/ml than those without EM （ 30.58 ± 19.94,26.82 ± 17.34 ） pg/ml, and there was significant difference （ P 〈 0.05 ）. In women with stage Ⅰ - Ⅱ of EM, the levels of IL-8 and TNF-α were （ 117.41 ± 87.92） pg/ml and （70.35 ± 29.14） pg/ml respectively, and there was significant difference（ P 〈 0.05 ）. No significant difference was found in the levels of IL-8, TNF-α in the peritoneal fluid in the proliferative and secretary phase between EM group and control group（ P 〉 0.05 ）. There was no significant correlation between the level of IL-8 and that of TNF-α in EM group. Conclusion The increase of levels of IL-8, TNF-α in peritoneal fluid of EM patients and their concentration suggests that the cytokines from macrophages may contribute to the development of EM.
出处
《广西医学》
CAS
2007年第4期476-478,共3页
Guangxi Medical Journal
基金
广西自然科学基金课题(桂科自0542082)。
