摘要
[目的]了解儿童接种甲肝疫苗后血清抗-HAV含量与时间的效应关系，为制订甲肝疫苗免疫接种程序提供科学依据。[方法]2004年，从攀枝花钢铁（集团）公司中小学校、幼儿园抽取接种过甲肝疫苗的1～11岁儿童533名进行调查。[结果]调查533人，血清抗-HAV阳性率为80．68％，其中1～5岁（仅接受初种）者为79．81％，6～11岁（已加强接种）者为81．25％（P〉0．05）；抗-HAV含量（IU／L）为（55．14±33．18），其中1～5岁儿童为（56．99±33．69），6～11岁儿童为（53．91±32．83）（P〉0．05）。初免儿童血清抗-HAV含量与接种后的时间存在负相关关系（r=-0．202，P〈0．01），加强接种儿童血清抗-HAV含量与加强接种时间无相关关系（P〉0．05）。[结论]儿童甲肝疫苗初免后血清抗-HAV在一定时间内仍维持较高水平，在5岁或稍后时间均可进行加强接种。
[Objective]To understand the relation of Anti-HAV content in serum and time-effect after immunization with hepatitis A in children,provide scientific basis for programmed immunization. [Methods]Investigation was conducted in 533 vaccinated children aged 1-11 from middle, primary schools and kindergartens of Panzhihua Steel Group in 2004. [Results]Of the 533 children investigated, 80.68 % of them was Anti-HAV positive in serum. Among them, the positive rate was 79.81% in aged 1-5 （ initial vaccination）. It was 81.25% in aged 6-11（booster dose）（ P 〉0.05）. The content of Anti-HAV was （55.14±33. 18） （IU/L）. It was （56.99±33.69） and （53.91±32.83） in the children aged 1-5 and 6-11 respectively （ P 〉0.05）. There was a negative correlation of the content of Anti-HAV in the serum of initially vaccinated children with the duration of vaccination （ r =-0. 202, P 〈0.01）. There was no correlation of the content of Anti-HAV in children （booster dose） with the duration of vaccination（ P 〉0.05）. [ConClusion]The titer of Anti-HAV can maintain high level for a period after initial hepatitis A vaccination,booster dose can be given to the children aged 5 or later.
出处
《预防医学论坛》
2007年第6期492-493,共2页
Preventive Medicine Tribune
关键词
甲型病毒性肝炎疫苗
接种
抗体
Vaccine of viral hepatitis A
Vaccination
Antibody
