摘要
目的将佩尔地平和硝酸甘油进行比较,探讨佩尔地平治疗高血压急症的降压稳定性及对心率的影响。方法共120例高血压急症患者随机的接受佩尔地平或硝酸甘油静脉注射治疗。比较用药后1h内每5min的滴速调整和心率变化情况。结果佩尔地平组与硝酸甘油组分别需经(2.01±0.43)次、(3.65±0.21)次滴速调整,达到目标血压,两组间差异有统计学意义(P<0.05);佩尔地平组心率由用药前的(82.15±5.67)次/min增加至用药后的(89.89±4.57)次/min,用药前后比较差异无显著性(P>0.05)。硝酸甘油组由用药前的(81.14±7.48)次/min增加至用药后的(103.76±6.87)次/min,用药前后比较差异有显著性(P<0.05)。结论佩尔地平可以平稳降压,对心率的影响较小,为较理想的在急诊科使用的控制高血压急症的药物。
Objective To evaluate the stability of blood pressure control and impact on heart rate of nicardipine in the treatment of hypertension emergency by comparing it with nitroglycerin. Methods 120 patients with hypertension emergency were treated with continuous intravenous injection of nicardipine or nitroglycerin randomly. Comparing the times that regulated drop rate and changes of heart rate each 5 minutes for 1 hour after used the medication .Reslts （1）To achieve the target blood pressure,the nicardipine group needed （2.01 ± 0.43 ）times to regulate the drop rate while the nitroglycerin group needed（3.65 ± 0.21 ）times,the difference between two groups was significant. After used the medication, the heart rate of nicardipine group increased from （ 82.15 ± 5.67 ） per minute to（ 89.89 ± 4.57 ） per minute, there was insignificant difference （ P 〈 0. 05 ） ; and the nitroglycerin group increased from （ 81.14 ± 7.48 ） to （ 103.76 ± 6.87 ） （ P 〈 0. 05 ）, there was significant difference. Conclusion For emergency department, nicardipine is an ideal medication in the treatment of hypertension emergency, with less impact on heart rate.
出处
《四川医学》
CAS
2007年第5期497-499,共3页
Sichuan Medical Journal
关键词
高血压急症
佩尔地平
硝酸甘油
hypertension emergency
nicardipine
nitroglycerin
