摘要
目的研究帕金森病(PD)患者是否存在脑干听觉传导通路与视觉传导通路的损害。方法应用意大利产Reporter型-4通道诱发电位仪对PD患者(男20例,女12例)、非帕金森病患者(对照组,男19例,女11例)进行脑干听觉诱发电位(BAEPⅠ、Ⅲ、Ⅴ峰潜伏期(PL)及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ峰间潜伏期(IPL))、视觉诱发电位(VEPP100PL)检测。结果PD患者BAEP异常率为50%,其中ⅢPL异常率为22%,ⅤPL异常率为19%;ⅢPL为(3.87±0.30)ms,ⅤPL为(5.79±0.30)ms。Ⅲ-Ⅴ>Ⅰ-Ⅲ为31%;与对照组比较(ⅢPL(3.56±0.22)ms,ⅤPL(5.48±0.26)ms)差异有统计学意义(t=5.83,5.85;P<0.01)。PD患者P100PL为(105.17±12.42)ms,对照组为(98.62±9.46)ms,2者相比差异有统计学意义(t=2.49,P<0.05)。结论帕金森病患者除存在黑质-纹状体病变外,可能还存在脑干听觉传导通路与视觉传导通路的损害;听觉诱发电位与视觉诱发电位可作为临床评价帕金森病的客观指标。
Aim： To study whether brain stem auditory and visual passageway are impaired in patients with Parkinson disease（PD）. Methods： A total of 32 patients with PD and 30 patients with non-neurological disease were selected, The Reporter type-4 channels evoked potential machine （Italy） was used to check brainstem auditory evoked potential（BAEP） and visual evoked potential（VEP）. Indexes of BAEP including peak latency（PL） of wavesⅠ、Ⅲ、Ⅴ and inter-peak latency （IPL） of waves Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ and the indexes of VEP （P100PL） were determined. Results：BAEP： the abnormal rate of the PD patients was 50%. PL of wave Ⅲ and wave V was 22% and 19% , respectively. The wave Ⅲ PL （ （3.87 ± 0.30） ms） and wave V PL （ （5.79 ± 0.30） ms） of the PD patients were different from those in the control group （（3.56±0.22） ms, （5.48±0.26） ms,t=5.83,5.85, P 〈 0.01）. VEP： the P100PLofthePD patients was higher than that in the control group （ （105.17 ± 12.42） ms, （98.62 ±9.46） ms,t =2.49, P 〈 0.05）. Conclusion： There are brain stem auditory and visual pathway impairment in PD patients except for substantianigra-striatum lesion. BAEP and VEP can be taken as sensitive and objective indicators for clinical evaluation of PD.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2007年第3期558-560,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
帕金森病
脑干听觉诱发电位
视觉诱发电位
Parkinson disease
brainstem auditory evoked potential
visual evoked potential
