摘要
纳洛酮为阿片受体拮抗剂,能竞争拮抗应激状态下大量阿片肽(内啡肽、强啡肽、脑啡肽)产生的病理生理效应,如抑制呼吸,引起支气管痉挛,使血压下降,加重心脑缺血、缺氧等。目前已广泛应用于临床各领域,包括用于循环系统、神经系统、呼吸系统、消化系统及心肺复苏、急性中毒的抢救等。
Naloxone is opiate receptor antagonist, which can exert a lot of pathophysiological effects including in inhibiting respiratory, inducing bronchospasm, decreasing blood pressure and aggratating cerebral ischemia and hypoxia by competitively antagonize a quantity of opioid peptide（ endorphin dynorphine enkephalin）. Now this drug has been widely applied in all fields in clinic including circulatory system, nervous system, respiratory system, digestive system as well as cardio-pulmonary resuscitation, salvage of acute poisoning and so on.
出处
《医学综述》
2007年第10期771-773,共3页
Medical Recapitulate
关键词
纳洛酮
阿片受体拮抗剂
临床应用
Naloxone
Opiate receptor antagonist
Clinical application
