摘要
非甾体抗炎药（non-steroidal anti-inflammatory drugs，NSAIDs）应用广泛，不仅可用于抗炎、镇痛，在防治肿瘤、阿尔茨海默病及脑保护等方面也发挥一定疗效。过去认为其药理作用与抑制环氧合酶-2（COX-2）有关，而其副作用与抑制COX-1有关。近期的研究则发现，COX-1和COX-2在炎症反应部位和胃肠道、肾脏等器官均有表达，NSAIDs的药理作用和不良反应均与两者密切相关；同时发现特异性COX-2抑制剂因打破体内COX-1与COX-2的平衡而具有潜在心血管危险性。因而传统所谓“COX-2抑制作用越特异，副作用越小”的观点可能是错误的。
NSAIDs are widely used as antiinflammation and analgesic drugs and may have therapeutic effects on prevention or treatment of tumor and Alzheimer disease, as well in brain protection. Studies have showed that both COX-1 and COX-2 are present in inflammation sites, gastrointestinal tract, kidney, and et al, raising the possibility that both of them are associated with the pharmacologic and side effects of NSAIDs. Discoveries that specific COX-2 inhibitors may have potential cardiovascular risks by breaking the balance between COX-1 and COX-2 make the traditional believing of COX-2 ＂the more specific the less adverse effect＂ incorrect .
出处
《国际麻醉学与复苏杂志》
CAS
2007年第2期122-125,共4页
International Journal of Anesthesiology and Resuscitation
