摘要
目的比较定量CT(QCT)和双能X线骨密度仪(DXA)所得测定值与灰重密度的相关性以及两种方法所得体积骨密度的偏离度,探讨QCT测量BMD的临床应用价值。材料与方法取15节猪腰椎椎体,去除周围软组织及附件,分别用QCT及DXA两种方法测量骨密度,再将去附件椎体灰化,将各自测得的总骨矿含量及骨密度与灰化后得到的椎体的灰重以及灰重密度比较。计算出DXA测量的体积骨密度,QCT测得的皮质骨密度、松质骨密度以及DXA测量得到的体积骨密度分别相对灰重密度的偏离度。结果QCT与DXA测量结果与灰重、灰重密度均有显著相关性(P<0.005),其中以DXA测得总骨矿含量与灰重的相关性最显著(r=0.9995)。且相对灰重密度,QCT测得松质骨密度的偏离度(平均值0.1489)低于DXA测量得到的体积骨密度的偏离度(平均值0.2708)(P<0.05)。结论QCT和DXA都是判断骨矿含量和诊断骨质疏松症较好的方法;QCT测量松质骨密度更接近于作为标准值的灰重密度;QCT测量松质骨密度比DXA测量骨密度能更好、更准确地反映骨质疏松的骨代谢变化。
Objective To compare the relationship of values measured by two different bone density measure methods （QCT and DXA） with bone ash density, and evaluate the clinic value of QCT in bone density. Materials and Methods 15 pig lumbar vertebral bodies were recruited. After removal of surrounding parenchyma and adjunct, BMD was measured by both QCT and DXA. The adjunct-removed vertebrae were incinerated. The gross value of BMC and BMD respectively measured by QCT and DXA were compared with the bone ash weight and bone ash density of incinerated vertebrae. After calculated the volume BMD measured by DXA, we further calculated the skewness of cortical BMD,trabetical BMD measured by QCT and the volume BMD measured by DXA compared with bone ash density. Results The correlation of trabetical BMD,cortical BMD measured by QCT and bone ash weight, bone ash density were at a high level of significance （ P 〈 0. 005 ）, and the correlation of BMC measured by DXA and the bone ash weight was the highest （ r = 0. 9995） o The skewness of trabetical BMD （Average is 0. 1489） was lower than the skewness of the volume BMD measured by DXA （Average is 0.2708）. Conclusion Two bone density measure methods （QCT and DXA） are both good methods to measure BMD and diagnose osteoporosiso The trabetical BMD measured by QCT is more close to bone ash density（ true BMD）. Changes of bone metabolism in osteoporosis can be better and more accurately reflected BMD measured by QCT than that by DXA.
出处
《临床放射学杂志》
CSCD
北大核心
2007年第5期504-507,共4页
Journal of Clinical Radiology
关键词
双能X线
骨密度
定量CT
Doal energy X-ray Bone mineral density Quantitative computed tomography
