摘要
目的了解血管紧张素原(AGT)、血管紧张素转换酶(ACE)、血管紧张素Ⅱ1受体(AT1R)基因多肽对IgA肾病的发生发展的影响。方法选择了64例IgA肾病患者和80例健康献血者,分别测定AGT、ACE和AT1R基因多肽性,并观察患者的尿蛋白,肾功能、血压。结果①患者具有ACE DD基因型者24小时尿蛋白定量(2.59±0.75)g明显高于ACEⅡ基因型者(1.80±0.57)g,两组间差异具有统计学意义(P<0.01);ACE DD基因型患者的血肌酐(134.0±22.5)μmol/L明显高于ACEⅡ基因型患者(92.0±19.2)μmol/L,两组间差异具有统计学意义(P<0.01)。②具有AGT TT基因型患者的24 h尿蛋白定量(2.32±0.78)g,明显高于AGT MM基因型(1.79±0.58)g和MT基因型(1.87±0.63)g,差异具有统计学意义(P<0.01);具有AGT TT基因型患者的血肌酐(135.0±23.8)μmol/L明显高于AGT MM基因型(98.9±17.3)μmol/L和MT基因型(105.1±25.3)μmol/L,差异具有统计学意义(P<0.01)。③患者具有AT1R AA AC CC基因型之间血压、血肌酐、24 h尿蛋白定量差异无统计学意义。④ACE与AGT联合作用结果发现ID+TT组24 h尿蛋白(2.10±0.81)g高于其他基因组,血肌酐(110.4±25.7)μmol/L高于其他基因组,但差异无统计学意义(P>0.05)。DD+TT组及DD+MT亦有24 h尿蛋白升高的趋势,但无统计学意义。结论肾素-血管紧张素系统的基因多肽性与IgA肾病进展相关。联合基因分析结果无统计学意义。提示需加大样板数,加入IgA肾病其他易感基因联合分析。
Objective To investigate the influence on IgA nephropathy evolution from gene polymorphism of angiotensinogen（AGT）,angiotensin-conventing enzyme（ACE）,angiotensin Ⅱ 1 receptor（AT1R）. Methods Sixty-four cases of IgA nephropathy patients and 80 cases of health blood donors were respectively measured their gene polymorphism from AGT ACE AT1 R, and patients＇ urinary protein, renal function, blood pressure were tested. Results 024 hour urinary protein excretion quantity was obviously much higher from the patients with ACE DD gene （2.59 ± 0.75） g than the Ones with ACE Ⅱ gene （1.80±0.57） g（ P 〈0.01）. The serum creatinine was obviously higher from the patents with ACE DD gene （134.0±22.5） μmol/L than the ones with ACE Ⅱ gene（92.0±19.2） μmol/L（ P 〈 0.01）. （2） 24 hour urinary protein excretion quantity was obviously higher from these patients with AGT TT gene （2.32±0. 78） g,than those patients with AGT MM gene （1.79±0.58） g and MT gene （1.87±0.63） g（ P 〈0.01）. The difference among the three groups showed significance difference. The serum creatinine was obviously higher from the patients with AGT TT gene（135. 0±23. 8） μmol/L,than those patients with AGT MM gene （98.9±17.3） μmol/L and MT gene （105.1 ± 25.3） μmol/L （P 〈 0.01）. The difference among the three gtoups had notable statstic significance. （3）There were no notable differences on blood pressure,serum creatinine,24 hour urinary protein excretion quantity among the patients＇ group with ATIR AA AC CC gene. （4）By observing ACE and AGT together, 24 hour urinary protein excretion quantity was obviously higher from these patients group ID＋ TT （2.10 ± 0.81） g, compared with the rest groups,also serum creatinine from group ID＋ TT （ 110.4 ± 25.7） μmol/L, being the highest among the rest groups（ P 〉0.05）, and 24 hour urinary protein excrention quantity from DD＋ TT group and DD＋ MT group showed ascending tendency,but no statistic significance.
出处
《临床荟萃》
CAS
北大核心
2007年第10期685-688,共4页
Clinical Focus
关键词
肾小球肾炎
IGA
尿分析
蛋白尿
核苷类
血压
基因结构
glomerulonephritis, IGA
urinalysis
proteinuria
nucheosides
blood pressure
genes, structural
