摘要
目的:总结进行角膜移植手术患者的病因学资料,并与国外相应统计资料比较。方法:收集2001-12/2005-12在南昌大学医学院第一附属医院眼科接受角膜移植手术的260例患者(260眼)的临床资料做以统计,内容包括性别、年龄,与角膜移植相关的临床诊断、手术方法等,患者均知情同意。患者的病种统计以出院时第一诊断为基准。260例患者中行单纯板层角膜移植125例,单纯穿透性角膜移植63例,联合羊膜覆盖33例,联合角膜缘干细胞移植术20例,联合结膜瓣遮盖术19例。术后半年进行视力评估,视力<3.7为盲。结果:260例角膜移植患者全部进入结果分析,无脱落。①260例患者中男162例,女98例,年龄(24±19)岁。角膜移植的病因按病例数由多至少排列,首位为角膜炎后角膜白斑,计86例(占3.08%),尤以病毒性角膜炎为主;外伤后角膜疤痕病变居第2位,计78例(占30%),随后为角膜溃疡并穿孔、蚕食性角膜溃疡、圆锥角膜、角膜皮样瘤、角膜营养不良、角膜失代偿、角膜葡萄肿以及角膜原位癌。角膜炎后角膜白斑病毒性角膜炎后最为多见,而国外类似的统计表明大泡性角膜病变占据首位。②术后半年260例角膜移植患者的脱盲率达94%。结论:与发达国家角膜移植最常见病因为大泡性角膜病变不同,角膜炎后角膜白斑、外伤后角膜疤痕、角膜溃疡并穿孔依次是国内角膜移植最常见的原因。
AIM： To summarize the etiological data of patients after keratoplasty and compare it with the similar studies from abroad.
METHODS： A total of 260 patients （260 eyes）, who received keratoplasty, were selected from Department of Ophthalmology, First Affiliated Hospital, Medical College, Nanchang University between December 2001 and December 2005 for statistics. The clinical data of these patients included sex, age, clinical diagnosis related to corneal transplant, operation method and so on. The patients all knew the fact and agreed to participate the trial. Entity was based on the first diagnosis when discharge. Among the 260 patients, there were simple layers corneal transplant in 125 cases, simple penetrativity corneal transplant in 63 cases, combined amnion coverage in 33 cases, combined limbus corneae stem cell transplantation in 20 cases and combined conjunctival flap covenng operation in 19 cases. Sight was evaluated half years after operaticn, and sight less than 3.7 expressed as blind.
RESULTS： Totally 260 patients after corneal transplant were involved in the result analysis, no drop-out. （1）Of the 260 patients, there were 162 males and 98 females, aged （24±19） years. The leading indications of keratoplasty in order of their decreasing frequency, were keratoleukoma after keratitis in 86 （3.08%） cases, especially viral keratitis, corneal scar affection in 78 （30%） in 78 cases, followed by corneal ulcer combined with perforation, nibbled corneal ulcer, keratoconus, corneal dermoid, corneal dystrophy, corneal decompensation, corneal staphyloma and corneal carcinoma in situ. Viral keratitis after keratoleukoma was the mostly common, while bullous keratopathy was in the first place at abroad. （2）Taking off blind rate reached 94% in 260 corneal transplant patients half years after operation.
CONCLUSION： Different from the mostly common etiology of corneal transplant is buiious keratopathy in developed countries. Keratoleukoma after keratitis, corneal scar after external in
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第16期3119-3121,共3页
Journal of Clinical Rehabilitative Tissue Engineering Research
