摘要
目的 探讨吡拉西坦及高压氧联合应用对军人慢性精神分裂症患者事件相关电位N400（简称N400）的影响。方法 将临床疗效已达显著进步以上的47例慢性精神分裂症患者,随机分为研究组（23例）和对照组（24例）,在吡拉西坦及高压氧联合治疗前、后,对2组患者分别进行N400检查和阳性症状与阴性症状量表（PANSS）评定。结果 治疗前2组比较,N400检查和PANSS评定均差异无显著性（P〉0.05）。与治疗前比较,研究组N400潜伏期[（523±112）ms、（453±89）ms]缩短,波幅[（5.1±2.2）μV、（6.8±2.9）μV]增高（P〈0.05）,其中潜伏期[（453±89）ms、（519±96）ms]与对照组治疗后比较差异有显著性（P〈0.05）;PANSS反应缺乏和阴性因子分较治疗前均明显降低（P〈0.05）,与对照组比较差异有显著性（P〈0.05）。结论 吡拉西坦及高压氧联合应用可以改善慢性精神分裂症患者的言语认知功能和部分精神症状。
Objective To study the therapeutic effects of piracetam and hyperbaric oxygen on cognitive impairment of chronic schizophrenics. Methods 47 remission inpatients with chronic schizophrenia were randomly assigned to the observational group（ n =23 ）and the control group（ n= 24）. Therapeutic alliance of piracetam and hyperbaric oxygen was administered to the observational group for 30 days continuously. Two groups were studied with the event-related potentials N400 （N400） and the positive and negative syndrome scale （PANSS） before and ＇after treatment. Results There was shortened latency and heightened amplitude of N400 in the observational group after treatment （ P 〈 0.05 ）. Compared with controls, N400s in the observational group manifested shorter latency after treatment （ P〈0.05 -0.01 ）. There was significant difference in the marks of negative gene and reaction lack gene in the PANSS between the observational group and the control group after treatment （ P 〈 0.01 ）. Conclusion Therapeutic allianee of Piracetam and hyperbaric oxygen proves to be effective in the treatment of cognitive impairment of inpatients with chronic schizophrenia.
出处
《中国行为医学科学》
CSCD
2007年第5期428-429,共2页
Chinese Journal of Behavioral Medical Science
