摘要
目的:探讨脑损伤后血浆D-二聚体的动态变化规律及其意义。方法:采用家兔脑损伤模型,应用金标法测定伤前及伤后2、4、6、12、24h,3、5、7d耳缘静脉血液D-二聚体含量,并观察其行为变化。结果:脑损伤后6h血浆D-二聚体即较前升高(P<0.05),并继续升高,第3天升高最为显著(P<0.01),第3～5天达峰值,第7天开始下降。同时观察到家兔伤后即出现跛行,且逐渐加重,第3～5天不能站立,第7天又开始跛行。而假手术组血浆D-二聚体及其行为无明显变化。结论:急性脑损伤的早期即可出现纤溶异常,动态检测血浆D-二聚体含量有助于了解脑损伤的演变过程。
Objective： To explore plasma D-dimer changes in different time and their significance after cerebral injury, Methods： The cerebral injury model was made to observe the behavior of rabbits and the level of plasma D-dimer at 2nd, 4th, 6th. 12th and 24th hours as well as at days 3,5 and 7 respectively, Result： Plasma D-dimer at the 6th hour was higher than before and continued to increase, It was significantly higher at days 3 and 5 than other time and decreased 7 clays later. The rabbits ira cerebral injured group were lame in the left leg after cerebral injury, They were unable to stand at days 3 arid 5 ,arid they were lame in the left leg again 7 days later, While the behavior of rabbits and the level of plasma D-dimer in sham operation group were normal. Conclusion： Fibrinolysis disorder happened in early stage after cerebral injury. Detection of plasma D-dimer could help to judge, the change and degree of brain parenchyma injury and provide a laboratorial evidence for the clinical treatment.
出处
《陕西医学杂志》
CAS
北大核心
2007年第5期530-531,540,共3页
Shaanxi Medical Journal
基金
西安市科委2001年科研项目(NoYG200114)
