摘要
目的:探讨冠心舒贴抗心肌缺血的药理作用。方法:对大鼠采用舌下静脉注射脑垂体后叶素,使动物产生急性心肌缺血模型,以心电图ST及T波产生的变化为指标,观察给药后的对抗作用,以验证冠心舒贴的临床疗效。结果:与生理盐水组比较,冠心舒贴高、低剂量组虽然不能明显对抗垂体后叶素所致大鼠T波的增值(P>0.05),但有降低T波增值趋势,且冠心舒贴同剂量组能有效提高心肌缺血阴性率(P<0.05)。结论:冠心舒贴对大鼠急性心肌缺血有保护作用。
Objective： To investigate the Anti - myocardial ischema pharmacological action of Guanxinshu patch. Methods ： The acute myocardial ischemia model was established by injecting hypophysin in ranine vein in rats. Based on the variation of ST wave and T wave on the electrocardiogram,we observed antagonistic action after administration to validate cura- tive effect of Guanxinshu patch. Results ： Compared with N. S group,the low and high dose groups of Guanxinshu patch could not antagonize the T wave increment caused by the injection of hypophysin in ranine vein in rats（ P 〉 0. 05 ） ,but they could degrade the tendency of T wave increment. Furthermore,Guanxinshu patch highdose group could raise MI negative rate（ P 〈 0.05 ）. Conclusions ： Guanxinshu patch has protective effect on acute myocardial infarction.
出处
《黑龙江医药》
CAS
2007年第3期230-231,共2页
Heilongjiang Medicine journal
关键词
冠心舒贴
贴剂
抗心肌缺血
药理学实验
Guanxinshu patch
patch
Anti - myocardial ischemia
harmacological action
