摘要
目的旨在分析脑梗死合并代谢综合征患者的临床特征及与脑血管病变程度的相关性。方法脑梗死患者585例按NCEP-ATPⅢ诊断标准分为代谢综合征组和非代谢综合征组。回顾性地比较两组患者临床特征,分析代谢综合征与脑血管病变程度的相关性。结果脑梗死患者585例中有290例(49.6%)合并代谢综合征。代谢综合征组的体质量指数、腰围、动脉血压、总胆固醇、三酰甘油、尿酸、空腹血糖、餐后2h血糖、糖化血红蛋白均显著高于无代谢综合征组;而高密度脂蛋白胆固醇水平显著低于后者;前者结构性影像(CT)大灶梗死和多灶梗死发生率和重型神经功能缺损积分均显著高于后者。相关分析显示,脑血管病变程度与患者腰围、动脉血压、总胆固醇、三酰甘油、糖化血红蛋白、空腹血糖及餐后2h血糖水平呈明显正相关(P<0.05),与高密度脂蛋白胆固醇呈负相关(P<0.01)。结论脑梗死合并代谢综合征患者使动脉粥样硬化危险因子更加聚集,脑血管病变程度更加严重,应进行全面脑血管危险因素防治,以改善预后。
Objective To explore clinical characteristics of patients with cerebral infarction（CI） complicated with metabolic syndrome（MS） and their correlation with severity of cerebrovascular stenosis. Methods A total of 585 cases with CI were retrospectively studied. The patients were catogorized in to groups with and without MS according to NCEP-ATP Ⅲ diagnostic criteria. Severity of cerebrovascular were evaluated by CT. Results Two hundred ninty cases（49.6%） complicated with MS showed higher body mass index （BMI）, waist circumference, blood pressure, serum total cholesterol（ TC）, triglyceride （ TG）, uric acid （ UA）, fasting blood glucose （FBG）, two hours postprandial blood glucose （2 h PBG）, glucosylated hemoglobin A1c（ HbA1c）, and lower high-densitylipoprotein-cholesterol（ HDL-C） than those without MS. Larger size and multiple infarcts and more serious score of neurological deficit were shown in patients complicated with MS. Severity of cerebrovascular disease disclosed by CT was positively related to levels of waist circumferene, blood pressure, TC, TG, HbAlc, FBG and 2 h PBG while in versely related to the levels of HDL-C （ r=-1.23, P〈0. 01）. Conclusion Patients with CI complicated with MS usually associated with multivessel changes and more severe stenosis. Comprehensive control of multiple cerebrovascular risk factors in order to improve the prognosis of CI is advocated.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2007年第4期311-314,共4页
Chinese Journal of Hypertension
关键词
脑梗死
代谢综合征
脑血管病变程度
Cerebral infarction
Metabolic syndrome
Severity of cerebrovascular stenosis
