摘要
目的观察硬膜外注射酚甘油治疗晚期癌痛的疗效及不良反应。方法选择失去手术机会或拒绝手术的晚期癌症患者42例,硬膜外间隙注射10％酚甘油镇痛,观察镇痛效果及并发症的发生。结果40例患者阻滞区域疼痛消失,占95．2％,其中有28例阻滞区域以外部位疼痛逐渐加剧,仍需依赖阿片类药物镇痛且用量渐增,1月后用量接近治疗前水平,仅12例治疗后阿片类药物用量显著减少。全组出现低血压、胃肠胀气、尿潴留、双下肢无力的比例分别为76．2％(32例)、85．7％(36例)、19．0％(8例)、14．3％(6例),但多在1周内消失。结论硬膜外注射酚甘油能有效消除阻滞区域的癌痛,长期并发症也较少发生,但单独应用本法难以取得满意的效果,综合治疗仍应成为晚期癌痛治疗的主要手段。
Objective To observe the effect and adverse reaction of phenol glycerin in epidural space to treat the advanced cancer pain. Methods Forty two patients with advanced cancer pain who lost the chance of operation or refuse operation were injected 10% phenol glycerin in epidural space to treat their severe pain. The analgesic effect and complications were observed. Results Pain in the area of blockade disappeared in 40 cases, but the pain out of the blocked area was aggravated. The opiods needed was increased. One month later the opiods dose was nearly as the same as before. The doses of opiods in the other 12 cases were decreased markedly after injection. The complications included hypotention （32 cases, 76.2% ） ,flatulence （36 cases,85.7% ） ,retention of urine （8 cases, 19% ） ,adynamia of lower extremities （6 cases, 14.3% ）. However, these symtoms disappeared after one week. Conclusion Epidural phenol glycerin is an effective method to treat the advanced cancer pain and the complications is seldom. But the area of pain relieve is limited to the blocked, combined treatment remains the method to treat the advanced cancer pain.
出处
《实用疼痛学杂志》
2007年第2期100-102,共3页
Pain Clinic Journal
关键词
硬膜外腔
甘油
治疗
疼痛
肿瘤
Epidural Space
Glycerin
Therapy
Pain
Neoplasms
