摘要
目的:探讨减瘤手术联合术后腹腔热灌注化疗或免疫治疗等综合治疗方法对腹膜恶性间皮瘤的治疗效果.方法:腹膜恶性间皮瘤17例分为3组:联合治疗组(减瘤手术+术后腹腔热化疗或联合DC免疫治疗,n=11),单独全身化疗组(n=4)和未治疗组(n=2).回顾性分析其临床资料及治疗经过,所有患者全部随访,观察生存期.结果:17例均经组织病理学确诊,其中小细胞型2例,上皮型5例,弥漫浸润型4例,未明确分型6例.随访时间5-67(平均35)mo,中位生存期32.5 mo,其中联合治疗生存期约35.5 mo,单独全身化疗生存期约11.3 mo,未治疗者生存期约4.5 mo.联合治疗组患者生存期较其他两组延长.结论:腹水细胞学检查、剖腹探查及腹腔镜活检为腹膜恶性间皮瘤的主要诊断方法.采用减瘤手术治疗联合术后腹腔热灌注化疗或免疫治疗等综合治疗,可以提高患者生存期.
AIM： To discuss the efficacy of surgical treatment combined with intraperitoneal hyperthermic perfusion （IPHP） chemotherapy or immunotherapy for malignant peritoneal mesothelioma （MPM）.
METHODS： Seventeen MPM patients were divided 3 groups. The former two groups （n = 11, n = 4） were treated with operation plus IPHP chemotherapy or immunotherapy and systematic chemotherapy, respectively, while the latter group （n = 2） received no treatment. The clinical data of the 17 cases were analyzed retrospectively. All the patients were followed up to observe the survival time.
RESULTS： All the patients, including 3 cases of small cell type, 5 cases of epithelial type, 4 cases of diffuse infiltration type and 6 unclassified cases, were diagnosed by pathological examination. The follow-up time was 5 to 67 months, and the medium survival time was 35 months. The survival time was 35.5 months in the combined treatment group, 11.3 months in the systematic chemotherapy group, and 4.5 months in the untreated group. The survival time was longer in the former one group than that in the latter two.
CONCLUSION： The diagnosis of MPM mainly depends on hydroperitoneal cytology, exploratory laparotomy and laparoscopy biopsy. The survival time can be prolonged by cytoreductive surgery combined with IPHP chemotherapy and immunotherapy.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第9期1041-1044,共4页
World Chinese Journal of Digestology
关键词
腹膜肿瘤
间皮瘤
诊断
联合疗法
Peritoneal neoplasm
Mesothelioma
Diagnosis
Combined treatment
