摘要
目的:探讨尿路移行细胞癌(transitional cell carcinoma,TCC)患者服用含马兜铃酸(aristolochic acid,AA)成分药物的情况和与AA相关TCC的临床特点。方法:对2000年1月～2006年3月间我院住院的112例尿路TCC患者服用含AA成分药物等情况进行调查,并对服药情况和临床特点作进一步分析。结果:112例TCC患者中有18例(16.1%)曾服用含AA成分药物,其中2例诊断马兜铃酸肾病。涉及药物有排石冲剂(2例)、冠心苏合丸和龙胆泻肝丸(共14例)、含关木通或广防己中药煎剂(2例)。均按常规剂量,除1例外17例均为间断服药,自开始服药至发现肿瘤的平均时间为11.1年。12/18例(66.7%)为女性,15/18例(83.3%)首发表现为间断全程无痛性肉眼血尿。肿瘤累及上尿路7例、下尿路6例,上下尿路同时累及5例。治疗上均按外科常规处理,6/18例(33.3%)术后肿瘤复发。结论:尿路TCC患者服用含AA类药物的情况比较多见,本组服含AA类药物的TCC患者中女性较多,肿瘤累及上下尿路数基本相同,其他临床特点与普通人群尿路TCC的特点相同。
Objective： To probe the status of patients with urinary transitional cell carcinoma who have ever taken the medicine containing aristolochic acid（AA）, and the clinical characteristics of urinary transitional cell carcinorna（TCC） associated with AA. Methods：To investigate the status of 112 TCC patients after taking the medicine containing AA, who were hospitalized in our hospital from Jan. 2000 to March 2006. To further analyze the medicine - taking and clinic characteristics of the patients who have ever taken the medicine containing AA. Results：Eighteen（16.1% ）of the 112 patients had a history of taking AA- containing Chinese medicine, and 2 of them were diagnosed as aristolochic acid nephropathy（AAN）. The medicines taken by above - mentioned 18 patients are as followed： urinary calculus removing powder preparation for infusion（2 cases）, Muskone and Longdan liver- purging pill（ 14 cases）, Chinese medicine apozem which include Guangrnutong and kuangfang chi （2 cases）. All patients took the medicine at routine doses intermittently except one patient. The average time between the beginning of taking AA - containing drugs and the detection of TCC was 11.1 years, twelve （66.7 % ） of the 18 patients were female. The first symptom in the fifteen （83.3 % ） of 18 cases was intermittent anodynia haematuria. As for 7 cases of the patients, the TCC involved upper urinary tract; for 6 cases of the patients, the TCC involved lower urinary tract, and for 5 cases of the patients, the TCC involved upper and lower urinary tract. All 18 patients were treated surgically. The relapse rate after operation was 33.3 % （6/18）. Conclusion： TCC; patients were often found have ever taken the medicine containing AA, Among this group of TO2 patients who has ever taken the medicine containing AA, the female patients are more than the male patients, The numbers of patients with TCC involved upper and lower urinary tracts were the same, Other clinical characteristics of above 18 patients were si
出处
《中国中西医结合肾病杂志》
2007年第4期212-214,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
关键词
马兜铃酸
尿路移行细胞癌
药物代谢
临床特点
Aristolochic acid Transitional cell carcinoma Medicament Clinic charsct erist
