摘要
BACKGROUND： Recently, it has been reported that blood lead level lower than 24 μ mol/L can lead to learning and cognitive deficits. OBJECTIVE： To investigate the relationship of lead level in foremilk and early neurobehavioral development of neonates taking lead level in foremilk as lead exposure index. DESIGN： A controlled observation. SETTING： Maternal and Child Health Center, Shanxi Children＇s Hospital. PARTICIPANTS： Totally 128 neonates of full-term normal delivery, 76 male and 52 female, from Shanxi Provincial Maternal and Child Health Center and Jiexiu Maternal and Child Health Center were involved in this study. All the involved neonates had no peripartal ischemic/hypoxic history. The corresponding puerperants were aged （27 ±5 ）years. They had no various acute and chronic diseases during pregnancy, and family history of neurological disease as well as occupational lead exposure. Informed consents of detected items were obtained from the puerperants. METHODS： ①Determination of lead level in foremilk- Altogether 128 foremilk samples, 1 mL each, were collected between January and February 2005. The same amount of violet acid was added to each sample. After foremilk was fully dissolved, 0.2 mL solution was taken for determining lead level with atomic absorption spectrometer in graphite stove. The determined process strictly followed the internal quantity control of laboratory and was involved in the blind quality control of Institute of Environmental Health of Chinese Academy. ②Participants grouping： Totally 128 neonates were involved, and the normal reference value of lead level of foremilk was 0.06 - 0.48 μ mol/L. The involved neonates were assigned into high-level lead group （≥ 0.24 μ mol/L, n =60） and low-level lead group （〈 0.24 μ mol/L, n =68）. ③Assessment of neurobehavioral development of neonates： Neurobehavioral development level of neonates who was born 24 to 72 hours was assessed with 20-item neonatal neurobehavioral determination method, which involved b
BACKGROUND： Recently, it has been reported that blood lead level lower than 24 μ mol/L can lead to learning and cognitive deficits. OBJECTIVE： To investigate the relationship of lead level in foremilk and early neurobehavioral development of neonates taking lead level in foremilk as lead exposure index. DESIGN： A controlled observation. SETTING： Maternal and Child Health Center, Shanxi Children＇s Hospital. PARTICIPANTS： Totally 128 neonates of full-term normal delivery, 76 male and 52 female, from Shanxi Provincial Maternal and Child Health Center and Jiexiu Maternal and Child Health Center were involved in this study. All the involved neonates had no peripartal ischemic/hypoxic history. The corresponding puerperants were aged （27 ±5 ）years. They had no various acute and chronic diseases during pregnancy, and family history of neurological disease as well as occupational lead exposure. Informed consents of detected items were obtained from the puerperants. METHODS： ①Determination of lead level in foremilk- Altogether 128 foremilk samples, 1 mL each, were collected between January and February 2005. The same amount of violet acid was added to each sample. After foremilk was fully dissolved, 0.2 mL solution was taken for determining lead level with atomic absorption spectrometer in graphite stove. The determined process strictly followed the internal quantity control of laboratory and was involved in the blind quality control of Institute of Environmental Health of Chinese Academy. ②Participants grouping： Totally 128 neonates were involved, and the normal reference value of lead level of foremilk was 0.06 - 0.48 μ mol/L. The involved neonates were assigned into high-level lead group （≥ 0.24 μ mol/L, n =60） and low-level lead group （〈 0.24 μ mol/L, n =68）. ③Assessment of neurobehavioral development of neonates： Neurobehavioral development level of neonates who was born 24 to 72 hours was assessed with 20-item neonatal neurobehavioral determination method, which involved b
基金
Key Technologies Research and Development Program of Shanxi Province, No. 041074
