摘要
目的:研制盐酸加巴喷丁缓释片。方法:利用单因素优化设计法优化处方制备工艺,建立HPLC法测定释放度。结果:最佳处方为盐酸加巴喷丁180 mg,K15M型HPMC 150 mg,CMC·Na 50 mg,可压性淀粉20 mg,5%PVP(K25)95%的乙醇溶液适量,0.5%硬脂酸镁作润滑剂。结论:该优选条件制备的加巴喷丁缓释片工艺简单,体外释药具有明显的12 h缓释作用。
Objective： To prepare gabapentin sustained-release tablets. Method ： The haplo-factor analysis test was used. A method for determination of release was established in vitro and the release rate of gabapentin sustained-release tablets was determined by HPLC. Result： Gabapentin sustained-release tablets was prepared with gabapentin 180 mg, K15M HPMC150 mg,CMC-Na50 mg,amylum pregelatinisatum 20 rag,5% PVP（ K25 ）95% and 0.5% magnesium stearate was quantum ,the tablet weight was 400 mg. Conclusion： The gabapentin sustained-release tablets have a conspicuous sustained effect for 12 h in vitro.
出处
《中国药师》
CAS
2007年第5期440-442,共3页
China Pharmacist
关键词
加巴喷丁
缓释片
HPLC
Gabapentin
Sustained-release tablets
HPLC
