摘要
为研究家族性高血压遗传方式，采用家系分析和分离分析方法，对６３个家族性高血压家系包括１４０个核心家系进行了分析。家系分析表明家族性高血压存在着明显的垂直传递现象；分离分析揭示Ａ×Ｕ，Ａ×Ａ婚配型都接受显性遗传分离比假设；所得结果支持家族性高血压为常染色体显性遗传。提示根据不同婚配类型，遗传方式可能不同，因此高血压有遗传异质性。研究结果将为家族性高血压的预防、诊断和治疗提供参考依据。
In order to study the genetic mode of familial hepertension, 63 pedigreses, including 140 nuclear pedigrees, of familial hypertension were investigated by means of pedigreed analysis and segregative analysis. Pedigreed analysis revealed that there is an evident phenomenon of vertical transmission in familial hypertension. It is hypothesed that there is a segregative ratio of dominant inheritance in A×U and A×A marital types, which is supported by segregative analysis. The data obtained suggest that the familial hypertension is an autosomal dominant hereditary disease. It is suggested that the genetic modes of familial hypertension could be different according to the different marital types of the patients. This finding suggests that the disease has a genetic heterogeneity. The reseach results will provide the reference evidence for the prevention, treatment and diagnosis of familial hypertension.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第2期108-111,共4页
Chinese Journal of Internal Medicine
关键词
高血压
遗传异质性
家族性
Hypertension Genetic Genetic heterogeneity
