摘要
目的观察2型糖尿病(DM)患者亚临床动脉粥样硬化(AS)与胰岛素抵抗(IR)的相关性。方法174例2型DM患者按有无颈动脉内膜-中膜(CA-IMT)增厚分为增厚组(92例),单纯DM组(82例),另设正常对照组(60例)。对3组均测空腹血糖(FBG)、空腹胰岛素(FIns),计算胰岛素抵抗指数(HOMA-IR)。结果增厚组HOMA-IR明显高于单纯DM组及正常对照组(均P<0.01),单纯DM组高于正常对照组(P<0.01)。结论2型DM伴亚临床AS与IR呈正相关,提示IR是2型DM及AS的危险因素。
Objective：To investigate the relationship of subclinical atherosclerosis and insulin resistance （IR） in type 2 diabetes mellitus （2DM）. Method： One hundred and seventy-four patients with 2DM were divided into two groups： G1 group with ninty-two cases whose carotid artery intirna-rnadia thickness （CA-IMT）〉1mm and G2 group with eighty -two cases without CA-IMT, and another sixty healthy cases were served as control. Homeostasis medal assessment （HomA） was applited to estimate IR. Result： HomA-IR in 2DM with CA-IMT〉 1 mm was significantly higher than those 2 DM and in the control group （1.66±0. 55 vs 1.1±0. 49, 0. 54±0. 27,P〈0. 01）. Conclusion： IR seems to be a risk factor of 2DM and diabetic carotid atherosclerosis.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2007年第4期265-267,共3页
Journal of Clinical Cardiology
关键词
糖尿病
非胰岛素依赖型
胰岛素抵抗
动脉粥样硬化
Diabetes mellitus, non-insulin-dependent
Insulin resistance, Atherosclerosis
