摘要
本文通过对不同孔隙率和不同孔径的聚乳酸组织工程支架在模拟体液(SBF)中的降解性能的研究,探讨支架结构对聚乳酸组织工程支架在SBF溶液中降解进程的影响。研究发现:孔径适中的200-300微米致孔剂制得的聚乳酸组织工程支架材料在降解1周后比其它两种孔径(致孔剂粒径100微米以下、致孔剂粒径300-400微米)的支架材料的分子量更高,支架的降解性能更稳定;孔隙率越高支架材料的分子量降低得越慢。聚乳酸组织工程支架的失重率并不随着降解时间的增长而逐步增大,而是呈起伏状态,这是由于组织工程支架在SBF溶液中既有降解进程,又有沉积进程造成的。
In the paper, the degradabilities of poly（lactic acid） tissue engineering scaffolds with different pore size and pore ratio were studied to find the influence of poly（lactic acid） scaffolds structure on its degradability in simulated body fluid （SBF）. It was found that the performance of scaffolds with mezzo pore size （200-300 μm） was even and did not change extremely. So, 200-300 μm was appropriate pore size. At the same time, it was found that the bigger the pore ratio was, the slower the rate of materials＇ molecular weight decrease was and the smaller the lost weight rate of scaffolds was. It was possible that when the pore ratio was small, the transgression of acidic degraded produces was difficult and they encircled the scaffolds and became the catalyzer of degradation. The weightlessness of scaffolds did not increase with the prolong of degrading time. The reason maybe was that when the scaffolds＇ materials were degrading, the ions in SBF were depositing on the surface of scaffolds.
出处
《材料科学与工程学报》
CAS
CSCD
北大核心
2007年第2期221-224,共4页
Journal of Materials Science and Engineering
关键词
支架结构
聚乳酸
组织工程支架
SBF溶液
降解
scaffold structure
poly（lactic acid）
tissue engineering scaffold
simulated body fluid
degradation
