期刊文献+

头孢噻呋对实验性感染鸡白痢沙门氏菌病的药效学研究 被引量:1

Pharmacodynamical Studies of Ceftiofur in Chickens Experimentally Induced with Salmonella pullorum
下载PDF
导出
摘要 研究了头孢噻呋对实验性感染鸡白痢沙门氏菌的防治效果。结果显示,头孢噻呋体内疗效良好,治疗组与预防组的治愈率、有效率、相对增重率均不同程度高于感染对照组(P<0.05或P<0.01);头孢噻呋的治疗效果高剂量组与中剂量组无显著差异(P>0.05),高剂量组与低剂量组差异显著(P<0.05);头孢噻呋的中剂量组与头孢曲松、氨苄西林组的疗效相比均差异显著(P<0.05或P<0.01)。实验结果表明,头孢噻呋按0.1mg/只的剂量肌肉注射,每日一次,可对鸡白痢沙门氏菌病起到有效的防治效果。 This paper described the pharmacodynamical studies of ceftiofur in chicken experimentally induced with S. pullorum. The results showed that ceftiofur had excellent therapeutic effects on this infection. The healing rate, effective rate and relative weight gain rate of all experiment groups were obviously better than those of positive control group(P 〈0.05 or P 〈0.01 ). The high dose of ceftiofur showed the similar therapeutic effects with the middle dose (P 〉 0.05 ) and excellent effects than the low dose ( P 〈 0.05 ). Comparing with ceftriaxone and ampicillin, the middle dose of ceftiofur could effectively cure the disease (P 〈 0.05 or P 〈 0.01 ). According to the results of the experiment, chicken injected with the middle dose of ceftiofur could prevent the disease.
出处 《中国兽药杂志》 2007年第4期46-48,共3页 Chinese Journal of Veterinary Drug
关键词 头孢噻呋 鸡白痢沙门氏菌病 药效学 ceftiofur Salmonella pullorum disease pharmacodynamics
  • 引文网络
  • 相关文献

参考文献5

  • 1丁焕中,陈杖榴.兽用抗生素头孢噻呋的研究进展[J].中兽医医药杂志,2000,19(4):17-21. 被引量:23
  • 2戴自英..临床抗菌药物学[M].北京:人民卫生出版社,1985:549.
  • 3俞树荣主编..微生物学和微生物学检验 第2版[M].北京:人民卫生出版社,1988:489.
  • 4Jaglan P S, Arnold T, Kubicek M F, et al. Metabolism of ceftiofur. Nature of Urinary and Plasma Metabolism in Rats and Cattle[J]. Journal of Agricultural and Food Chemistry, 1989, (37) :1112 -1118. 被引量:1
  • 5Salmon S A, Watts J L, Yancey R J. In Vitro Activity of Ceftiofur and Its Primary Metabolism, Deuroylceftiofur, against Organisms of Veterinary Importance[ J]. J Vet Diagno Invest, 1996,8:332 -336. 被引量:1

二级参考文献30

  • 1[1]Yancy R J Jr,Kinney M L,Roberts B J et al.Ceftiofur sodium,abroad-spectrum cephalosporin: evaluation in vitro and in vivo in mice[J].Am J Vet Res,1987,48 (7): 1050~3 被引量:1
  • 2[2]Salmon S A,Watts J L,Yancey R J Jr.In vitro activity of ceftiofur and its primary metabolite,defuroylceftiofur,against organisms of veterinary importance [J] .J Vet Diagno Invest,1996,8(3): 332~6 被引量:1
  • 3[3]Shryock T R,White D W,Werner C S.Antimicrobial susceptibity of Moraxella bovis [J].Vet Microbiol,1998,61 (4): 305~9 被引量:1
  • 4[4]Salmon S A,Watts J L,Aarestrup F M,et al.Minimum inhibitory concentrations for selected antimicrobial agents organisms isolated from the mammary glands of dairy heifers in New Zealand and Denmark [J].Dairy Sci,1998,81(2) :570~8 被引量:1
  • 5[5]Watts J L,Salmon S A,Yancey R J Jr,et al.Antimicrobial susceptibility of microorganisms isolated from mammary glands of dairy heifers[J].J Dairy Sci,1995,78:1637~1648 被引量:1
  • 6[6]Watts J L,Yancey R J Jr,Salmon S A,et al.A 4-year survey of antimicrobial susceptibility trends for isolated from cattle with bovine rispiratory disease in North America[J].J Clin Microbiol,1994,32 (3): 725~731 被引量:1
  • 7[7]Post K W,Cole N A,Raleigh R H.In vitro antimicrobial susceptibility of Pasteurella haemolytical and Pasteurella multocida recovetred from cattle with bovine respiratory disease complex[J].J Vet Diagn Invest,1991,3(2) :124~6 被引量:1
  • 8[8]Van Duijkeren E,Van Klingeren B,VuIto A G,et al.In vitro susceptibility to antimicrobial drugs of 62 Salmonella strains isolated from horses in the Netherlands [J].Vet Microbiol,1995,45:19~26 被引量:1
  • 9[9]Cervantes C C,Brown M P,Gronwall R,et al.Pharmacokinetics and concentration of ceftiofur sodium in body fluids and endometrium after repeated intramuscular injections in mares [J].Am J Vet Res,1993,54(4) :573~5 被引量:1
  • 10[10]Salmon S A,Watts J L,Case C A,et al.Comparison of MICa of ceftiofur and other antimicrobial agents against bacterial pathogens of swine from the United States Canada,and Denmark [J].J Clin Microbiol,1995,33 (9): 2435~44. 被引量:1

共引文献22

同被引文献8

引证文献1

;
使用帮助 返回顶部