摘要
目的评价手术加放疗治疗下咽癌的疗效和毒副反应。方法1998年4月至2000年3月在齐鲁医院接受手术加放射治疗的下咽癌患者32例，分期T2-4N0-2M0，手术采用咽喉肿瘤切除术及颈部淋巴结清扫术，术后2～4周伤口完全愈合后进行放射治疗，剂量为55～66Gy，观察治疗毒副反应，放疗结束后定期随访，采用Kaplan—Meier法进行生存率评估。结果所有患者均顺利完成治疗，Ⅰ、Ⅱ级治疗毒副反应主要为放射性咽部黏膜炎和皮肤放射性损伤，无Ⅲ级及以上的治疗毒副反应发生。3、5年生存率分别为70.6％和57.9％。结论下咽癌患者手术后加放射治疗的毒副反应患者能耐受，取得了较好的生存率。
Objective To evaluate the effect and toxicity of adjuvant radiotherapy for patients of hypopharynx cancer after operation, Methods A retrospective review of 32 postoperative patients with clinical stage T2-4N0-2M0 hypopharynx cancer treated with adjuvant radiotherapy between April 1998 and March 2000 in Qilu hospital was performed. All the patients received pharyngolaryngectomy and elective neck dissection, 2-4 weeks after operation a total dose of 55-66 Gy radiotherapy was delivered at the rate of 1.8-2 Gy per fraction. After radiotherapy regular follow-up was undertaken, Treat-related toxicity was observed and overall survival was estimated by the Kaplan-Meier method. Results All the patients completed the protocol therapy successfully, The most common grade Ⅰ and Ⅱ toxicity was mucositis of throat and radiation injury to skin. No grade Ⅲ or higher toxicity was observed, The 3-and 5-year survival rate was 70. 6% and 57.9% ,respectively. Conclusion Adjuvant radiotherapy after operation has lower toxicity which patients can endure. And the overall survival rate is satisfying.
出处
《国际肿瘤学杂志》
CAS
2007年第4期312-313,317,共3页
Journal of International Oncology
关键词
下咽肿瘤
放射疗法
综合疗法
Hypopharyngeal neoplasms
Radiotherapy
Combined modality therapy
