摘要
目的探讨HBV感染者的肝脏病理和免疫组化与部分临床生化指标的关系。方法采用一秒钟经皮肝脏穿刺活检法取得肝组织,进行病理形态学观察以及免疫组化法检测组织中HBsAg的表达,同步检测部分血清生化指标进行统计学分析。结果慢乙肝轻、中度的临床与病理诊断符合率分别为72.7%和40%,肝硬化的符合率为18.1%。慢乙肝患者肝组织中HBsAg表达与炎症分级G无相关性,与TB升高程度呈负相关。肝组织的炎症分级G与ALT、纤维化分期S呈正相关。纤维化分期S与ALT、TB无相关性。结论慢乙肝和肝硬化的临床诊断和病理诊断一致性较低。慢性HBV感染者病毒清除可以造成肝细胞的损伤,但并不是主要原因。
Aim To study the correlation of the clinical pathology and serum biochemistry of 46 patients with chronic HBV infection. Methods Serum biochemical parameters of 46 patients were detected through percutaneous liver biopsy,we estimated the histopathologic injury of liver tissue and hepatic expression of HBsAg. Results According to the pathological diagnosis,the consistency of clinical diagnosis of mild and moderate chronic hepatitis B was 72.7% and 40% respectively,and cirrhosis was 18.1%. HBsAg expression in liver tissue with chronic hepatitis B have no correlation with histological inflammatory grade( G), and negative correlation with TB degree: G has positive correlation with ALT and histological fibrosis stage (S). Conclusions Clinical and pathologic diagnosis has low coherence. Viral clearance during chronic HBV infection is thought to cause the damage of liver tissue,but not the main reason.
出处
《安徽医药》
CAS
2007年第4期342-343,共2页
Anhui Medical and Pharmaceutical Journal