期刊文献+

46例慢性HBV感染者临床与肝组织病理及免疫组化相关性分析 被引量:2

Correlation of the clinical pathology and serum biochemistry of 46 patients with chronic HBV infection
下载PDF
导出
摘要 目的探讨HBV感染者的肝脏病理和免疫组化与部分临床生化指标的关系。方法采用一秒钟经皮肝脏穿刺活检法取得肝组织,进行病理形态学观察以及免疫组化法检测组织中HBsAg的表达,同步检测部分血清生化指标进行统计学分析。结果慢乙肝轻、中度的临床与病理诊断符合率分别为72.7%和40%,肝硬化的符合率为18.1%。慢乙肝患者肝组织中HBsAg表达与炎症分级G无相关性,与TB升高程度呈负相关。肝组织的炎症分级G与ALT、纤维化分期S呈正相关。纤维化分期S与ALT、TB无相关性。结论慢乙肝和肝硬化的临床诊断和病理诊断一致性较低。慢性HBV感染者病毒清除可以造成肝细胞的损伤,但并不是主要原因。 Aim To study the correlation of the clinical pathology and serum biochemistry of 46 patients with chronic HBV infection. Methods Serum biochemical parameters of 46 patients were detected through percutaneous liver biopsy,we estimated the histopathologic injury of liver tissue and hepatic expression of HBsAg. Results According to the pathological diagnosis,the consistency of clinical diagnosis of mild and moderate chronic hepatitis B was 72.7% and 40% respectively,and cirrhosis was 18.1%. HBsAg expression in liver tissue with chronic hepatitis B have no correlation with histological inflammatory grade( G), and negative correlation with TB degree: G has positive correlation with ALT and histological fibrosis stage (S). Conclusions Clinical and pathologic diagnosis has low coherence. Viral clearance during chronic HBV infection is thought to cause the damage of liver tissue,but not the main reason.
出处 《安徽医药》 CAS 2007年第4期342-343,共2页 Anhui Medical and Pharmaceutical Journal
关键词 肝病 肝组织学检查 免疫组化 hepatits liver biopsy hepatic histology
  • 相关文献

参考文献8

二级参考文献35

  • 1严家春,刘健虎,马勇.1052例肝炎肝内血管病变的形态观察[J].肝脏病杂志,1995,3(3):155-157. 被引量:33
  • 2[1]Chu C M,Yeh C T,Sheen I S,et al.Subcellular localization of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B[J].Gastroenterology,1995,109:1926-1932. 被引量:1
  • 3[2]Mosnier J F,Scoazec J Y,Marcellin P,et al.Expression of cytokine dependent immune adhesion molecules by hepatocytes and bileduct cells in chronic hepatitis C[J].Gastroneterol,1994,107:1457-1468. 被引量:1
  • 4[4]Comanescu V,Ardeleau C,Zaharia B,et al.Histopathologic and immunohistochemical correlation sin virus B chronic hepatitis[J].Romj Morphol Embryol,1997,43:169-172. 被引量:1
  • 5Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N,Kiernan TW, Wollman J.Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hevatologu 1981;1:431-435. 被引量:1
  • 6Chevallier M,Guerret S,Chossegros P,Gerard F,Grimaud JA.A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens:comparison with morphometric studies, Hepatology 1994;20:349-355. 被引量:1
  • 7Fattovich G, Brollo L, Alberti A, Giustina G, Pontisso P, Realdi G,Ruol Ao Chronic persistent hepatitis type B can be a progressive disease when associated with sustained virus replication.J Hepatol 1990;11:29-33. 被引量:1
  • 8团体著者,中华传染病杂志,1995年,13卷,241页 被引量:1
  • 9严家春,肝脏病学杂志,1994年,2期,39页 被引量:1
  • 10严家春,刘健虎,马勇.肝血管阻塞在乙型肝炎肝硬变中的作用[J].临床与实验病理学杂志,1997,13(3):206-208. 被引量:11

共引文献14031

同被引文献16

  • 1Iloeje UH,Yang HI,Su J,陆伟(摘译),张占卿(审校).根据循环乙型肝炎病毒载量预测肝硬化的危险性[J].世界感染杂志,2006,6(4):396-396. 被引量:211
  • 2FATTOVICH G,GIUSTINA G,SCHALM S W,et al. Occurrence of hepatocellular carcinoma and decompen sation in western European patients with cirrhosis type B. The EUROHEP Study Group on Hepatitis B Virus and Cirrhosis[J~. Hepatology, 1995,21 : 77- 82. 被引量:1
  • 3LIAW YF, TAI D I, CHU C M, et al. The development of cirrhosis in patients with chronic type B hepatitis:a prospective studyEJ]. Hepatology, 1988,8 : 493 - 496. 被引量:1
  • 4LIAW Y F,LEUNG N,GUAN R,et al. Asian-Pacific consensus statement on the management o{ chronic hepatitis B:a 2005 update[J]. Liver Int,2005,25:472 -489. 被引量:1
  • 5YIM H J,LOK A S. Natural history of chronic hepati- tis B virus infection: what we knew in 1981 and what we know in 2005{-J~. Hepatology, 2006,43(2 Suppl 1) :S173- 181. 被引量:1
  • 6LOK A S, Mc MAHON B J. Chronic hepatitis B[J~. Hepatology, 2007,45 : 507 - 539. 被引量:1
  • 7HSU Y S,CHIEN R N,YEH C T,et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B 1-J~. Hepatology, 2002,35 : 1522- 1527. 被引量:1
  • 8YU M W,YEH S H,CHEN P J,et al. Hepatitis B vi- rus genotype and DNA level and hepatocellular carcino- ma: a prospective study in menFJ~. Natl Cancer Inst, 2005,97:265-572. 被引量:1
  • 9CHOU Y C,YU M W,WU C F,et al. Temporal rela- tionship between hepatitis B virus enhancer ]l/basal core promoter sequence variation and risk of hepatocel- lular carcinoma[J]. Gut, 2008,57 : 91 - 97. 被引量:1
  • 10CHEN C J,YANG H I,SU J,et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level[J~. JAMA, 2006,295 : 65 - 73. 被引量:1

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部