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唑来膦酸治疗恶性肿瘤骨转移的临床疗效观察 被引量:5

Clinical study on the effect of zoledrolic acid in treatment of malignant bone metastasis
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摘要 目的观察唑来膦酸对恶性肿瘤骨转移疼痛和转移灶的治疗效果。方法对恶性肿瘤骨转移者静脉注射唑来膦酸4 mg,每月一次,一个月为一周期,至少2周期后评价疗效及不良反应,疗效评价指标包括止痛效果,KPS评分的变化和转移灶的改变情况。结果疼痛完全缓解11例,有效31例,无效6例,有效率87.5%;KPS评分提高的中位数为10;骨转移灶CR1例,PR9例,MR11例,总有效率43.75%;不良反应为发热,恶心,腹胀等,发生率较低。结论唑来瞵酸对骨转移引起的疼痛有良好的止痛效果,对转移灶有较好的治疗作用,副作用少,值得临床应用。 Aim To observe the efficacy of zoledrolic acid to treat hone metastasis and to relieve pain. Methods Zoledrolic acid 4mg was given by infusion, the treatment was repeated at 1 month intervals, the effect and toxicity were evaluated after at least 2 cycles. The evaluated target included the relieving pain, the change of KPS and the change of metastatic focus. Results complete relief of pain was in 11 patients, partial relief 31 patients, no effect 6 patients with a total effective rate of 87.5% ; KPS rised median 10 ; among these patients with metastatic bone, complete response 1, partial response 9, micro response 11, the total effective rate was 43.75% ;the toxicity reactions were fever,nausea and abdominal distention,but the rate was low. Conclusion Zoledrolic Acid is effective to relieve the pain of metastatic bone cancer and is effective to treat metastatic focus, the side effect can be tolerated. It can be used in clinic.
作者 郑国甫
出处 《安徽医药》 CAS 2007年第4期305-306,共2页 Anhui Medical and Pharmaceutical Journal
关键词 唑来膦酸 恶性肿瘤 骨转移 zoledrolic acid relief of pain malignant tumor bone metastasis
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  • 1Coukell AJ,Markham A,Pamidronate:a review of its use in the management of osteolytic bone metastases,tumour-induced hypercalcaemia and Paget's disease of bone[J].Drugs Aging,1998,12:149-68. 被引量:1
  • 2Willington K,Goa KL.Zoledrolic acid:a review of its use in the management of bone metastases and hypercalcaemia of malignancy[J].Drugs,2003,63(4):417-37. 被引量:1
  • 3Novartis Pharma Stein AG.Zometa prescribing information.Stein:Novartis Pharma Stein AG,2004. 被引量:1
  • 4Rosen LS,Gorden D,Antonio BS,et al.Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma:a phase Ⅲ,double-blind,comparative trial[J].Cancer J 2001 Sep 31,7(5):377-87. 被引量:1
  • 5Green JR,Seltenmeyer Y,Jaeggi KA,et al.Renal tolerability profile of novel,potent bisphosphonates in two short-term rat models[J].Pharmacol Toxicol,1997,80:225-30. 被引量:1

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