摘要
目的通过诱发电位(EP)监测,探讨纳络酮在治疗心肺脑复苏中的疗效。方法对60例呼吸心跳骤停患者随机分为2组,30例采用常规治疗,另外30例常规治疗加纳络酮治疗,即纳络酮0.8mg,呼吸心跳停止后立即静注,以后前3天剂量为每日0.3mg/kg,后7天改为4.8mg/日。于用药后30min、24h、72h、120h监测正中神经短潜伏期体感诱发电位(SISEP)和脑干听觉诱发电位(BAEP)。对纳络酮治疗组与对照组诱发电位进行统计分析。结果纳络酮治疗组SISEP的N13-N20峰间潜伏期(N13-N20IPL)及BAEP的1-V波峰间潜伏期(I-VIPL)在药后均较对照组缩短且有显著性差异P<0.05。结论诱发电位监测结果表明:纳络酮能有效改善呼吸心跳骤停患者异常的神经电生理指标,对心跳呼吸骤停患者有明显的治疗作用。
Objective To evaluate the curative effect of Naloxome on respiratory and cardiac arrest. Methods Sixty patient with respiratory and cardiac arrest were randomly divided into treatment and control groups. In the control group 30 patients were treated by the routine method and in the treatment group 30 patients were treated by naloxone besides the routine method. Naloxone of 0.8mg were intravenously given immediately after respiratory and cardiac arrest, naloxone of 0.3mg/kg·d for first three days. and naloxone of 4.8mg per day was given again for the following seven days in the treatment group. Median nerve short latency somatosensory evoked potentials（SLSEP） and brain stem auditory evoked potentials （BAEP） were recorded 30 minutes, 24, 72 and 120 hours after the administration of drugs in both the group. The changes in the evoked potentials were analyzed statistically. Results N13-N20 interpeak latency（IPL） in SLSEP and the peak I-V IPL in BAEP after the administration of naloxone were significantly reduced in the treatment group compared to the control group（ P 〈0.05）. Conclusion The curative effect of naloxone on the patients with respiratory and cardiac arrest is good.
出处
《华南国防医学杂志》
CAS
2007年第2期15-17,共3页
Military Medical Journal of South China
基金
广州军区卫勤课题项目(2001A12)
关键词
纳络酮
诱发电位
呼吸心跳骤停
Naloxone
Evoked potentials
Respiratory and cardiac arrest
