摘要
目的探讨苯巴比妥负荷量联合安定治疗小儿惊厥持续状态的应用价值。方法选择57例惊厥持续状态患儿随机分为治疗组37例,对照组20例。两组均先予以安定0.2~0.3m g/kg静脉注射后,治疗组给予苯巴比妥负荷量10-20m g/kg在30-60m in内静滴,12h后给予维持量5m g/kg;对照组予以苯巴比妥5m g/kg静脉注射,将两组疗效进行对照。结果①治疗组总有效率94.5%,对照组75.0%,两组比较有显著性差异（2χ=4.63,P〈0.05）,惊厥控制时间较对照组短（P〈0.05）;②治疗组除个别患儿止惊后嗜睡外未见其他不良反应。结论苯巴比妥负荷量联合安定应用于小儿惊厥持续状态是安全快速有效的治疗方法,可以作为儿科抢救惊厥持续状态的常规方案。
Objective To investigate therapeutic effect of loading dose of phenobarbital combined with diazepam for status epilepticus （SE） of children, Methods 57 children with SE were divided into two groups randomly ： the study group （ n = 37 ） and the control group （ n = 20）, All of them were given 0.2 -0.3mg/kg of diazepam by intravenous injection at lmg/min, of speed firstly and loading dose（ 10 - 20mg/kg） of phenobarbital was given for 37 children in the study group by intravenous drip within 30 - 60minutes, then the maintenance dose （Smg/kg） of phenobarbital was given after 12 hours for 2 -3 days. While those children in the control group were given 5mg/kg of phenobarbital by intravenous injection. The therapeutic effects in the two groups were compared, Results （1）The total effective rate in the study group was 94, 5% ,while that in the control group was 75%, there was a significant difference （P 〈 0, 05 ）. The SE controlled time was shorter in the study group; （2） Any adverse effects except lethargy were not found in the study group. Conclusion As a conventional treatment, loading dose of phenobarbital combined with diazepam is effective and safe for status epilepticus of children in pediatrics.
出处
《中国妇幼健康研究》
2007年第2期113-114,共2页
Chinese Journal of Woman and Child Health Research
关键词
负荷量
苯巴比妥
安定
惊厥持续状态
loading dose
phenobarbital
diazepam
status epilepticus
