摘要
目的探讨胰岛素样生长因子-I与妊娠期高血压疾病发病的关系。方法选取30例妊娠期高血压疾病患者(疾病组)及10例同期住院待产正常孕妇(对照组)血清及胎盘标本,采用放射免疫方法检测两组血清中胰岛素样生长因子-I浓度水平,采用免疫组织化学SABC法检测胰岛素样生长因子-I在两组胎盘中的表达情况。结果疾病组胰岛素样生长因子-I水平(115.53±40.33)明显低于对照组(181.738±12.27),且随着疾病严重程度的增加而降低;疾病组与对照组胎盘组织胰岛素样生长因子-I表达部位无差异,在疾病组表达明显降低。胎盘胰岛素样生长因子-I表达强度与血清胰岛素样生长因子-I水平存在直线正相关。结论胰岛素样生长因子-I参与妊娠期高血压疾病发病。
Objective To study relationship between insulin-like growth factor-I（IGF-I） and hypertensive disorder complicating pregnancy and its clinical significance. Methods The serum and placenta samples of 30 women with hypertensive disorder complicating pregnancy （the study group） and 10 women with normal pregnancy （the control group） were taken. Radioimmunoassay （RIA） was used to detect level of IGF-I in the serum and immunohistochemical staining （ SABC method） was used to detect the expression of IGF-I in the placenta. SPSS 11.5 software was used for statistic analysis. P 〈 O. 05 was considered to have statistic significance. Results The serum level of IGF- I in the study group was significantly lower than that in the control group （ P 〈 O. 05 ） and with increase in severity of the disease, the expression of IGF-I protein was significantly lower in the study group. There was no difference in location of expression of IGF-I in the placental tissues both in the two groups. However, expression of IGF-I in the placental tissues in the two groups was significantly lower （P 〈0. 05）. There was a linear positive relationship between intensity of expression of IGF-I and serum level of it. Conclusion IGF-I in serum may involve in pathogenesis of hypertensive disorder complicating pregnancy.
出处
《中国妇幼健康研究》
2007年第2期105-107,共3页
Chinese Journal of Woman and Child Health Research
