摘要
目的:探讨复合牛骨形态发生蛋白(bBMP)的纤维蛋白胶(FS)强化去势绵羊椎弓根螺钉固定作用的生物力学效果.方法:选取4只去势绵羊腰椎2～6双侧共36个椎弓根随机分为3组:FS/bBMP组,磷酸钙骨水泥(CPC)组,空白对照组,每组12个椎弓根.FS/bBMP组钉道内注入复合bBMP的FS,CPC组注入CPC,空白对照组钉道内不作任何处理.拧入螺钉饲养3mo后取材.在材料试验机上进行轴向拔出试验和周期抗屈试验.结果:FS/bBMP组的最大拔出力为(909.98±155.65)N,CPC组为(994.20±122.78)N,两组差异无统计学意义(P>0.05).两组均明显高于空白对照组的(524.65±118.35)N,差异具有统计学意义(P<0.05).周期抗屈试验800个周期内,FS/bBMP组螺钉位移为(1.478±0.466)mm,CPC组为(1.274±0.393)mm,空白对照组为(1.978±0.531)mm,其中FS/bBMP组与CPC组两组差异无统计学意义(P>0.05),两组均小于空白对照组,差异有统计学意义(P<0.05).结论:在骨质疏松椎体内植入椎弓根螺钉时,添加复合bBMP的FS可显著提高螺钉稳定性.
AIM： To evaluate the biomechanical efficacy of fibrin sealant （FS） as a carrier compounded with bBMP in augmentation of pedicle screw fixation in osteoporotic sheep vertebrae. METHODS： Thirty-six lateral lumbar vertebras （L2-L6） from 4 female sheep with ovariectomy-induced osteoporosis were employed in this experiment. They were randomly divided into 3 groups： FS/bBMP augmented group, the screw track were filled with FS/bBMP; calcium phosphate cement （CPC） augmented group, the screw track were filled with CPC; and control group without augmentation. Meanwhile, the screws were implanted in each group consisting of 12 lateral lumbar vertebras. After three months＇ breeding, all the sheep were sacrificed. Axial pulling-out test and periodical bending resistance test were performed on each group. RESULTS ： Compared with the control group [ （524.65 ± 118.35） N], the maximal axial pulling-out strengths of FS/bBMP augmented group[ （909.98 ± 155.65） N] and of CPC augmented group [ （994.20 ± 122.78） N] were significantly increased （ P 〈 0. 05 ）, while no statistical significance （ P 〉 0.05） was found between the FS/bBMP augmented group and CPC augmented group. In the periodical bending resistance test within 800 cycles, the maximal offsets of FS/bBMP augmented group [ （ 1.478 ± 0. 466 ）mm ] and of CPC augmented group [ （1.274 ±0.393） ram] were smaller as compared with the control group [ （ 1. 978 ± 0. 531 ） mm] （ P 〈 0.05 ）, but there was no significant difference （ P 〉 0.05 ） between the FS/bBMP augmented group and CPC augmented group. CONCLUSION： Augmentation with fibrin sealant as a carrier compounded with bBMP can significantly strengthen the pedicle screw fixation in osteoporotie sheep vertebrae.
出处
《第四军医大学学报》
北大核心
2007年第7期627-630,共4页
Journal of the Fourth Military Medical University
