摘要
目的研究十全大补汤对荷瘤小鼠抑瘤作用及对荷瘤小鼠免疫功能的影响。方法以TA2移植性乳腺癌小鼠作为研究对象,给予50%SDT和灌胃,并给予化疗,以小鼠的体重、瘤重及脾内B淋巴细胞、T淋巴细胞增殖指数、IL-6,TNF-α,IL-2作为观察指标。结果50%SDT可明显改善荷瘤鼠的一般状况,抑制肿瘤的生长;明显增强脾内T淋巴细胞的增殖,并调节B淋巴细胞的增殖,显著提高荷瘤小鼠脾细胞的IL-2,IL-6和TNF-α的分泌。结论SDT可在体内抑制肿瘤的生长,并降低化疗药物对机体的免疫损伤作用。
Objective To study the effects of Shiquan Dabu Decoction on tumor - inhibition and immunity in mice with transplantable mammary cancer. Methods TA2 mice were randomly divided into four groups after vaccination of MA737 tumor tissue （ named control,50% SDT, CMF, CMF ＋ 50% SDT）. The weight, tumor weight, spleen cell proliferation, IL-6, IL-2 and TNF-α were measured. Results The results showed that 50% SDT inhibited the growth of the tumor. 50% SDT also enhanced the level of T lymphocyte proliferation and regulated the level of B lymphocyte proliferation and promoted the spontaneously secrete and stimulated secrete of IL-6, IL-2 and TNF-α in spleen cells. Conclusion SDT can inhibit tumor growth and lessen the damage of immunity caused by chemotherapy.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第4期F0003-F0004,共2页
Lishizhen Medicine and Materia Medica Research
