摘要
目的探讨老年糖尿病前期有无早期糖尿病肾病的改变。方法根据OGTT结果将68名老年人分为正常糖耐量(NGT)组和糖调节受损(IGR)组。测定尿微量白蛋白(mAlb)、转铁蛋白(TRF)、N-乙酰-B-D氨基葡萄糖苷酶(NAG)及视黄醇结合蛋白(RBP)。结果与TNG组比较,IGR组mAlb、NAG、RBP增高(P<0.01);IFG组RBP升高(P<0.01);IGT组四项指标均增高(P<0.01)。糖负荷后2h血糖水平及血浆胰岛素水平与四种肾脏相关蛋白均有关联。结论老年糖尿病前期存在早期肾脏损害,并与血糖和胰岛素水平相关。
Objective To explore whether early diabetic nephropathy changes in old patients with pre-diabetes. Methods 68 old subjects were divided into normal glucose tolerance （NGT） group and impaired glucose regulation （ IGR ） group according to oral glucose tolerance test （OGTr）resnlts to detect the excretion of urinary micro-albumin （mall））, transferrin （TRF）, N-acetyl-beta-D glucosaminidase （NAG） and retinal binding protein （RBP）. Results The excretion of urinary mall）, NAG and RBP were higher in IGR group compared with those in NGT group （ P 〈0.01 ）. Only the level of urinary RBP in IFG group was higher （ P 〈0.01 ）. The levels of urinary mall）, TRF, NAG and RBP in IGT group were all significandy higher than those in NGT group （P 〈0.01 ）. The 2 h plasma glucose （2 h PG） level of OGTT and serum insulin level correlated with the levels of urinary mAlb, TRF, NAG and RBP. Conclusions There are early renal damages in old patients with pre-diabetes, which is related to plasma insulin level and glucose level.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2007年第7期651-653,共3页
Chinese Journal of Gerontology
