摘要
骨组织工程是骨缺损修复和重建的主要发展方向,使用高效的种子细胞构建组织工程化骨,是目前研究的热点之一。研究者们利用组织工程和基因工程相结合的原理,通过转基因方法改造种子细胞,从而提高了种子细胞的成骨效率和组织工程化骨的质量。本文就目前研究较多的基因修饰的种子细胞情况作一综述。
Bone tissue engineering is a main development of the repair of bone defects. Using high efficient seed cells to construct tissue engineered bone is a challenge for the researchers. Based on the principle of tissue engineering and gene engineering , researchers used transgenic technique to improve the ossification of the seed cells and the quality of the tissue engineered bone. This review focuses on some gene modified seed cells. Supported by National Natural Science Foundation of China （Grant No.30400502） and Research Fund of Science and Technology Commission of Shanghai Municipality （Grant No. 04dz05601,05DJ14006,055407034,05QMX1426）.
出处
《中国口腔颌面外科杂志》
CAS
2007年第2期147-150,共4页
China Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金(30400502)
上海市科学技术委员会科研基金(04dz05601
05DJ14006
055407034
05QMX1426)
关键词
骨组织工程
基因
成骨作用
组织工程化骨
Bone tissue engineering
Gene
Osteogenesis
Tissue engineered bone
