摘要
为了探讨子宫动脉灌注化疗联合放射治疗局部晚期宫颈癌的效果,应用子宫动脉灌注化疗联合放疗(A组)和单纯放疗(B组)随机对照治疗局部晚期宫颈癌患者74例,A、B组各37例,比较近期疗效和远期疗效。结果A组近期有效率91·9%(34/37),B组为70·3%(26/37),χ2=5·64,P=0·018。1、3和5年生存率A组为97·3%、86·5%和81·1%;B组为83·8%、64·9%和56·8%,χ2值分别为3·95、4·70和5·11,P值分别为0·047、0·030和0·024。血液毒性反应主要表现白细胞下降,A组为78·4%,B组为56·8%,χ2=3·95,P=0·047。初步研究结果提示,子宫动脉灌注化疗联合放射治疗局部晚期宫颈癌较单纯放疗显著提高近期疗效及生存率,值得推广。
To explore the effect of uterne artery intrevenional chemotherapy combined with radiotherapy and simple radiotherapy in the treatment of local advanced cervical. For comparison of the uterne artery intrevenional chemotherapy combined radiotherapy （A group） and the simple radiotherapy （B group） in the treatment of patients with local advanced cervical cancer and 74 cases were randomized into two groups. The response and toxicities were compared by X^2 test. A group gave an all overall response rate of 91.9% （34/37）; B group gave an all overall response rate of 70.3%（26/37）（P〈0.05）. The survival rates of 1-year, 3-year and 5 year in A group were 97.30/00 86.5% ,81.1% respectively; and in B group 83.8%%,64.9% ,56.8%, respectively （P〈0.05）. The blood toxic reactions expressed mainly in the drop of white cell, and it was 78.4% in A group, 56.8% in B group （P〈0.05）. In local advanced cervical carcinoma patients treated with the uterne artery intrevenional chemotherapy combined with adiotherapy, 1-year , 3-year and 5-year survival rates were superior to those with the simple radiotherapy （P〈0.05）. For side toxicities, blood toxic reactions in A group was higher than that in those in B group （P〈0.05）.
出处
《中华肿瘤防治杂志》
CAS
2007年第4期304-306,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
宫颈肿瘤/治疗
灌注
局部
动脉
放射疗法
子宫/血液供给
cervix neoplasms/therapy
perfusion, regional
arteries
radiotherapy
uterus/blood supply
