摘要
目的:对特非那定片标准中溶出度检查与含量测定的流动相进行选择,统一为一个流动相。方法:采用高效液相色谱法。结果:流动相Ⅲ为乙腈-磷酸盐缓冲液(50:50),其出峰时间最短,峰形良好且专属灵敏。结论:建议将两个检测项目中的流动相统一为流动相Ⅲ。
Objective：To find a ideal and unified mobile phase both of dissolution test and content determination of terienadine tablets. Methods：HPLC was used. Results：The mobile phase Ⅲ[a mobile phase composed of acetonitrile-phosphate buffer（50 ： 50） ] was applied, tg is shorter, the peak shape is better and the methods are specific and sensitive. Conclusion： The mobile phase Ⅲ is recommended as a ideal and unified mobile phase of dissolution and determination for terfenadine tablets.
出处
《药学实践杂志》
CAS
2007年第2期98-99,共2页
Journal of Pharmaceutical Practice
关键词
特非那定片
高效液相色谱法
溶出度
含量测定
terfenadine tablets
HPLC method
dissolution
determination of content
