摘要
【目的】观察升清泄浊法中药制剂尿毒清胶囊(由附子、黄芪、大黄、法半夏、土茯苓等组成)对慢性肾功能衰竭(CRF)患者的临床疗效及其抗肾纤维化的作用。【方法】用简单随机化、前瞻性的研究方法,将78例慢性肾功能衰竭患者按1∶1分为治疗组和对照组。两组均给予低优质蛋白饮食、血压控制、纠正水电解质紊乱和酸碱平衡、利尿剂的使用、抗感染等基本治疗,治疗组在基本治疗的基础上加服尿毒清胶囊,对照组在基本治疗基础上加服包醛氧淀粉,两组均以4周为1个疗程,连续治疗2个疗程后统计结果。观察患者主要症状、证候和血红蛋白(Hb)、红细胞总数(RBC)、血清肌酐(SCr)、尿素氮(BUN)、内生肌酐清除率(CCr)、血清白蛋白(ALB)、血清总胆固醇(TCh)、甘油三酯(TG)、低密度脂蛋白—胆固醇(LDL-C)、高密度脂蛋白—胆固醇(HDL-C)、血清层粘蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)、透明质酸(HA)等实验室检测指标的变化情况。【结果】治疗组主要症状总计分、大部分症状单项计分均少于对照组(P<0.05或P<0.01),症状疗效和总体疗效均高于对照组(P<0.05或P<0.01);尿毒清胶囊能提高CRF患者血清ALB、HDL-C、CCr水平,降低TCh、TG、LDL-C、BUN、SCr、LN、PC-Ⅲ、HA水平(P<0.05或P<0.01),但对RBC、Hb的升高作用与对照组比较无显著性差异(P>0.05)。【结论】中药升清泄浊法制剂尿毒清胶囊不仅能改善患者临床症状,而且能改善患者的肾功能;对肾纤维化指标也有改善作用,说明该药具有良好的抗肾纤维化作用。
[Objective] To observe the therapeutic effect of Niaoduqing Capsule （NC）, which has the actions of lifting clear Qi and purging turbidity, for chronic renal failure （CRF） and to investigate its influence on kidney fibrosis parameters. [ Methods ] A prospective study was carried out in 78 CRF patients. The patients were equally randomized into two groups. Besides the basic treatment of feeding with small-dose high-quality protein, controlling blood pressure, maintaining water-electrolyte and acid-base balance, Group A received oxyamyli tectus aldehydum and group B received NC. Four weeks constituted one treatment course and the treatment lasted 2 courses. Before and after treatment, the scores of main symptoms and syndrome were counted, and laboratory parameters such as hematoglobin （Hb）, red blood cells （RBC） count, sennn creatinine （SCr）, blood urea nitrogen （BUN）, creatinine clearance （CCr）, albumin （ALB）, total cholesterol （ TC ）, triglyceride （TG）, low-density lipoprotein cholesterol （ LDL-C ）, high-density lipoprotein cholesterol （HDL-C）, serum laminin （LN）, precollagen-m （PC-Ⅲ） and hyaluronic acid （HA） were assayed. [ Results] Total scores of main symptoms and scores of most single symptom were lower, and effect on the symptoms and total therapeutic effect were better in group B than those in group A （ P 〈 0.05 or P 〈 0.01 ）. NC increased serum ALB, HDL-C and CCr levels, and decreased TC, TG, BUN, SCr, LN, PC-Ⅲ and HA （P 〈 0.05 or P 〈 0.01）. However, effect of NC on the increase of RBC and Hb was insignificant （ P 〉 0.05）. [Conclusion] NC has an effect on relieving symptoms of CRF, and improving renal function and kidney fibrosis parameters, indicating that NC exerts a better counteraction on kidney fibrosis.
出处
《广州中医药大学学报》
CAS
2007年第2期108-112,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
