摘要
[目的]探讨在高海拔地区创伤后机体血液流变学及凝血系统相关指标的变化及其临床意义。[方法]分别检测40例创伤骨折患者在伤后不同时间内血液流变学及凝血系统相关指标的变化，并与正常健康人进行比较。[结果]创伤组患者的血液粘度增高、红细胞聚集性增强，血浆廿颗粒膜蛋白（GMP-140）、血栓烷（TXB2）、纤维蛋白原（Fbg）、D-二聚体（D—D）的水平明显的增高，与正常人比较有显著性差异（P〈0．05，P〈0．01），其值在1～3d内达高峰，随后下降，5d仍明显高于正常人。[结论]高海拔地区，机体创伤后各项血液流变学及凝血系统的指标有明显变化，表现为浓、粘、聚、凝特性，动态观察可为临床上防治创伤后急性深静脉血栓形成提供一定的实验依据。
[Objective] To investigate the changes of indexes of hemorrheology and coagulative system in the blood of patients with severe trauma on highland, and to elucidate their clinical value. [Methods] Indexes of hemorrheology and coagulative system （GMP-140, TXB2, Fbg, D-D） in patients with severe trauma and normal group were observed simultaneouslyand analyzed. [Results] Whole blood viscosity, red blood cell aggregation, GMP-140, TXB2, Fbg and D- Dimer in patients with severe trauma were significantly higher than that of the healthy group （P 〈 0.05, P 〈 0.01）： the level was highest at 1 to 3 days after injury, and then decreased but still kept at higher level 5 days after injury. [Conclusion] The results suggest that there is a significant change in hemorrheological indexes and coagulative system in patients with severe trauma in hypoxia environment of high altitude area. The whole blood in the traumatic patients show a concentrated, viscous, appregative, hypercoagulate state. Studies on the dynamic mechanism of hemorrheological indexes and coagulative system may offer a base for the treatment of deep venous thrombosis （DVT） in post-traumatic patient.
出处
《武警医学院学报》
CAS
2007年第1期49-52,共4页
Acta Academiae Medicinae CPAPF
基金
武警部队后勤科研项目(WKH2002043)
关键词
高海拔
创伤
血液流变学
凝血系统
深静脉血栓形成
High altitude
Trauma
Hemorrheology
Coagulative system
Deep Venous Thrombosis
