摘要
目的：探讨典型及非典型冠状动脉痉挛患者是否具有相同动脉硬化危险因素。方法：以发作性夜间或静息性胸痛或胸闷为主要症状、经乙酰胆碱试验或非创伤性方法诊断为冠状动脉痉挛的患者为研究对象，根据胸痛或胸闷发作时心电图或动态心电图是否有ST段抬高分为典型冠状动脉痉挛和非典型冠状动脉痉挛组，比较两组患者的各种动脉硬化危险因素。结果：两组患者的吸烟率和血脂代谢紊乱发生率均高达50％以上，合并糖尿病和高血压病者亦在30％～50％之间。典型及非典型冠状动脉痉挛组的性别、高血压、HDL-C、TG、纤维蛋白原水平及冠心病家族史均无显著差别（P〉0．05），但与典型冠状动脉痉挛组相比，非典型冠状动脉痉挛组患者相对年轻，吸烟率、糖尿病和血脂代谢紊乱患病率及LDL—C水平更高，体重指数更大（P均〈0．05）。结论：冠状动脉痉挛与动脉粥样硬化具有相同的危险因素，非典型患者比典型冠状动脉痉挛患者合并有更多的危险因素和更高的危险水平。
Objective： To investigate if there is any different risk factors in patients with typical and atypical coronary artery spasm. Methods： The patients, with rest chest pain and diagnosed as coronary artery spasm by acetylcholine test or non-invasive diagnostic criteria, were divided into two groups of typical and atypical coronary artery spasm according to with or without electrocardiographic ST segment elevation during episode of spasm. The common atherosclerotic risk factors were compared between two groups. Results： More than 50% of patients were smokers and with dyslipidemia while 30%～50% of patients were with diabetes and hypertension in both groups. There were no significant difference in sex, hypertension, HDL-C, TG, fibrinogen and family history of coronary artery between the two groups （P 〉 0. 05）. However, the patients were younger and there were more smokers, diabetes, dyslipidemia, higher level of LDL-C and greater of BMI in atypical group than in typical group （P 〈 0. 05）. Conclusion： There are similar risk factors in patients with coronary spasm and with atherosclerosis. The patients of atypical group have more atherosclerotic risk factors and higher risk level than those of atypical group.
出处
《华夏医学》
CAS
2007年第1期6-7,共2页
Acta Medicinae Sinica
基金
广东省自然科学基金课题(032186)
关键词
冠状动脉痉挛
心绞痛/变异型
危险因素
胸痛
coronary artery spasm
variant angina pectoris
risk factor
chest pain
